TY - JOUR
T1 - Differential effect of ramadan fasting on intercellular adhesion molecule-1 (ICAM-1) in diabetes mellitus and non-diabetes mellitus patients
AU - Tahapary, Dicky L.
AU - Rizqa, Tasykuru
AU - Syarira, Cut Vania
AU - Lusiani, Lusiani
AU - Rizka, Aulia
AU - Wafa, Syahidatul
AU - Wisnu, Wismandari
AU - Edi Tarigan, Tri Juli
AU - Harbuwono, Dante Saksono
N1 - Funding Information:
This study was supported by a grant from the University of Indonesia (Grant No: NKB-1523/UN2.RST/HKP.February 05, 2020 ). We would like to thank all those who contributed to this study. We also would like to thank Cluster Metabolic and Vascular Aging, Indonesian Medical Education and Research Institute (IMERI) team for their support in this research.
Funding Information:
This study was supported by a grant from the University of Indonesia (Grant No: NKB-1523/UN2.RST/HKP.February 05, 2020). We would like to thank all those who contributed to this study. We also would like to thank Cluster Metabolic and Vascular Aging, Indonesian Medical Education and Research Institute (IMERI) team for their support in this research.
Publisher Copyright:
© 2023
PY - 2023/7
Y1 - 2023/7
N2 - Background: The month of Ramadan is a holy month for Muslims. During this month, Muslims do not eat, drink, or smoke from sunrise to sunset. Patients with type 2 diabetes mellitus (T2DM) will also fast from dawn to dusk, creating a unique opportunity to study the effects of dietary changes during fasting period. One of the interesting results of Ramadan fasting is its effect on endothelial dysfunction, measured using Intercellular Adhesion Molecule-1 (ICAM-1) as a biological marker of endothelial function. Aim: To determine the changes ICAM-1 levels in T2DM and non-DM patients during Ramadan fasting. Methods: A retrospective cohort study was performed on 26 T2DM patients and 21 non-DM, age-matched patients (aged 19–60 years). Measurement of metabolic parameters (systolic and diastolic blood pressure, total calorie intake, and intensity of physical activity), anthropometry (body weight, body mass index (BMI) and abdominal circumference), total dietary intake, and laboratory analysis (blood glucose fasting, HbA1c, lipid profile, ICAM-1) were done at 4 weeks before (T0) and 14 days after Ramadan fasting (T1). Result: The median ICAM-1 level in T2DM patients at T0 was 340.9 (193–505) ng/mL and at T1 was 312.3 (158–581) ng/mL, while the ICAM-1 level in non-DM patients at T0 was 482 (305–653) and at T1 was 398.4 (202–526) ng/mL. There was no significant difference of ICAM-1 level between study groups at both T0 and T1 (p > 0.05). Both T2DM and non-DM patients had lower ICAM-1 level following Ramadan fasting. However, only non-DM patients had significantly lower post Ramadan ICAM-1 (p = 0.008) Conclusion: There was a significant decrease in ICAM-1 level in both T2DM and non-DM patients after Ramadan fasting.
AB - Background: The month of Ramadan is a holy month for Muslims. During this month, Muslims do not eat, drink, or smoke from sunrise to sunset. Patients with type 2 diabetes mellitus (T2DM) will also fast from dawn to dusk, creating a unique opportunity to study the effects of dietary changes during fasting period. One of the interesting results of Ramadan fasting is its effect on endothelial dysfunction, measured using Intercellular Adhesion Molecule-1 (ICAM-1) as a biological marker of endothelial function. Aim: To determine the changes ICAM-1 levels in T2DM and non-DM patients during Ramadan fasting. Methods: A retrospective cohort study was performed on 26 T2DM patients and 21 non-DM, age-matched patients (aged 19–60 years). Measurement of metabolic parameters (systolic and diastolic blood pressure, total calorie intake, and intensity of physical activity), anthropometry (body weight, body mass index (BMI) and abdominal circumference), total dietary intake, and laboratory analysis (blood glucose fasting, HbA1c, lipid profile, ICAM-1) were done at 4 weeks before (T0) and 14 days after Ramadan fasting (T1). Result: The median ICAM-1 level in T2DM patients at T0 was 340.9 (193–505) ng/mL and at T1 was 312.3 (158–581) ng/mL, while the ICAM-1 level in non-DM patients at T0 was 482 (305–653) and at T1 was 398.4 (202–526) ng/mL. There was no significant difference of ICAM-1 level between study groups at both T0 and T1 (p > 0.05). Both T2DM and non-DM patients had lower ICAM-1 level following Ramadan fasting. However, only non-DM patients had significantly lower post Ramadan ICAM-1 (p = 0.008) Conclusion: There was a significant decrease in ICAM-1 level in both T2DM and non-DM patients after Ramadan fasting.
KW - Diabetes mellitus
KW - Intercellular adhesion Molecule-1 (ICAM-1)
KW - Ramadan fasting
UR - http://www.scopus.com/inward/record.url?scp=85163757120&partnerID=8YFLogxK
U2 - 10.1016/j.heliyon.2023.e17273
DO - 10.1016/j.heliyon.2023.e17273
M3 - Article
AN - SCOPUS:85163757120
SN - 2405-8440
VL - 9
JO - Heliyon
JF - Heliyon
IS - 7
M1 - e17273
ER -
