Diagnostic yield of the combined magnetic resonance imaging and magnetic resonance spectroscopy to predict malignant brain tumor

Rahmad Mulyadi, Andi Asadul Islam, Bachtiar Murtala, Jumraini Tammase, Mochammad Hatta, Muhammad Firdaus

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Brain tumor is a neoplasm originating from various type of intracranial tissue. Histopathology is the gold standard to diagnose brain tumor. However, due to its invasive nature, the biopsy procedure poses a substantial risk. Therefore, advanced imaging, such as conventional Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS), has been widely developed to determine brain tumor type. Conventional MRI has been a routine examination for a suspected brain tumor in Indonesia, and with the utilization of MRS, could theoretically improve the diagnostic yield. This study aims to find diagnostic properties of conventional MRI, Choline/Creatine and Choline/NAA ratio extracted from MRS, and as a combined parameter to differentiate brain tumor type. Methods: This cross-sectional study involved 52 patients who underwent conventional MRI, MRS, and histopathology examination for a suspected brain tumor. The cut-off from Dean Criteria of conventional MRI, Choline/Creatine and Choline/NAA ratio to classify tumor type was determined from the ROC curve and then the diagnostic parameters were calculated from cross-tabulation. Also, a novel approach was made with logical-mathematical equation (disjunction/ / “or” and conjunction/ / “and”) to combined parameter obtained from MRI and MRS to predict histopathological brain tumor type. Results: Conventional MRI combined with MRS improve diagnostic yield compared to a single parameter with a sensitivity of 87.5%, a specificity of 88.6%, accuracy of 88.5%, PPV of 58.3%, NPV of 97.5%, LR+ of 7.68, dan LR-of 0.1. Conclusion: Combination of conventional MRI and MRS parameter could improve the diagnostic yield in differentiating the type of brain tumor.

Original languageEnglish
Pages (from-to)239-245
Number of pages7
JournalBali Medical Journal
Volume9
Issue number1
DOIs
Publication statusPublished - 2020

Keywords

  • Brain tumor
  • Choline/Creatine
  • Choline/NAA
  • Dean Criteria

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