TY - JOUR
T1 - Diagnostic Performance of Mac-2-Binding Protein Glycosylation Isomer (M2BPGi), compared to Transient Elastography to Assess Liver Stiffness in Treatment Naïve Chronic Hepatitis C Patients
AU - Sulaiman, Andri Sanityoso
AU - Hasan, Irsan
AU - Lesmana, Cosmas Rinaldi A.
AU - Kurniawan, Juferdy
AU - Jasirwan, Chyntia Olivia Maurine
AU - Nababan, Saut
AU - Kalista, Kemal Fariz
AU - Hanifa, Rachmadianti Sukma
AU - Rachmani, Desti
AU - Gani, Rino Alvani
N1 - Funding Information:
This study was supported by the Ministry of Health of Republic Indonesia through Health Science and Technology Research Grant (No: HK.03.01/1/994/2020) and by the Sysmex Indonesia (No:PEA0006/MKT/ESI/XI/2019).
Funding Information:
The author would like to thank the National Institute of Health Research and Development, the Indonesia Ministry of Health, and Sysmex Indonesia for funding the study. Furthermore, the authors would also like to send gratitude to Raysha Afiff, Pertiwi Puji Lestari, and Dwi Handayu from the Hepatobiliary Division, Faculty of Medicine Universitas Indonesia for their excellent technical assistance on sample collection and processing.
Funding Information:
Andri Sanityoso Sulaiman received research grant from the Ministry of Health, Republic of Indonesia and Sysmex Indonesia Company. The funders had no role in the design of the study, in the collection, analysis, interpretation of data, in writing the manuscript, or in the decision to publish the result.
Funding Information:
This study was supported by the Ministry of Health of Republic Indonesia through Health Science and Technology Research Grant (No: HK.03.01/1/994/2020) and by the Sysmex
Publisher Copyright:
© 2022, Indonesian Society of Internal Medicine. All rights reserved.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - BACKGROUND: Liver fibrosis is an essential factor in the management of Hepatitis C virus infection. Its assessment is crucial in decision-making regarding the therapeutic decisions, and the patients' follow up. However, the established liver measurement methods have several limitations. Therefore, this study aims to assess the role of Mac-2-Binding Protein Glycosylation Isomer (M2BPGi) as a novel biomarker to measure liver stiffness in treatment naïve Chronic Hepatitis C Indonesian patients. METHODS: This study used a cross-sectional design to determine the correlation between serum M2BPGi and the degree of liver stiffness, Transient Elastrography, and differences in serum M2BPGi levels in chronic hepatitis C patients. Serum M2BPGi level and Transient Elastography results were evaluated in 56 Chronic Hepatitis C patients and 48 healthy controls. Pearson correlation analysis was conducted to find the correlation between the level of M2BPGi and Transient Elastography result. ROC analysis was conducted to find the optimum cut-off to assess fibrosis's degree among Chronic Hepatitis C Patients. RESULTS: The level of serum M2BPGi and Transient Elastography result was strongly correlated with the median level of serum M2BPGi. It was also significantly higher among Chronic Hepatitis C Patients than among healthy controls (r: 0.708, p<0.001; 0.590 COI vs. 4.130 COI, p<0.001). Among the Chronic Hepatitis C patients, the median serum of M2BPGi increased according to the degree of liver fibrosis: 1.500 COI (F0-F1), 2.985 COI (F2-F3) and 8.785 COI (≥F4). The optimum cut-off value for diagnosing significant fibrosis (F2-F3) was 1.820 COI (AUC: 90.8%) and for diagnosing cirrhosis (≥F4) was 3.770 COI (AUC: 89.3%). CONCLUSION: Serum M2BPGi was a reliable diagnostic tool for identifying liver fibrosis in Indonesian patients with Chronic Hepatitis C.
AB - BACKGROUND: Liver fibrosis is an essential factor in the management of Hepatitis C virus infection. Its assessment is crucial in decision-making regarding the therapeutic decisions, and the patients' follow up. However, the established liver measurement methods have several limitations. Therefore, this study aims to assess the role of Mac-2-Binding Protein Glycosylation Isomer (M2BPGi) as a novel biomarker to measure liver stiffness in treatment naïve Chronic Hepatitis C Indonesian patients. METHODS: This study used a cross-sectional design to determine the correlation between serum M2BPGi and the degree of liver stiffness, Transient Elastrography, and differences in serum M2BPGi levels in chronic hepatitis C patients. Serum M2BPGi level and Transient Elastography results were evaluated in 56 Chronic Hepatitis C patients and 48 healthy controls. Pearson correlation analysis was conducted to find the correlation between the level of M2BPGi and Transient Elastography result. ROC analysis was conducted to find the optimum cut-off to assess fibrosis's degree among Chronic Hepatitis C Patients. RESULTS: The level of serum M2BPGi and Transient Elastography result was strongly correlated with the median level of serum M2BPGi. It was also significantly higher among Chronic Hepatitis C Patients than among healthy controls (r: 0.708, p<0.001; 0.590 COI vs. 4.130 COI, p<0.001). Among the Chronic Hepatitis C patients, the median serum of M2BPGi increased according to the degree of liver fibrosis: 1.500 COI (F0-F1), 2.985 COI (F2-F3) and 8.785 COI (≥F4). The optimum cut-off value for diagnosing significant fibrosis (F2-F3) was 1.820 COI (AUC: 90.8%) and for diagnosing cirrhosis (≥F4) was 3.770 COI (AUC: 89.3%). CONCLUSION: Serum M2BPGi was a reliable diagnostic tool for identifying liver fibrosis in Indonesian patients with Chronic Hepatitis C.
KW - Chronic Hepatitis C
KW - Mac-2-Binding Protein Glycosylation Isomer
KW - Transient Elastography
UR - http://www.scopus.com/inward/record.url?scp=85145956604&partnerID=8YFLogxK
M3 - Article
C2 - 36624717
AN - SCOPUS:85145956604
SN - 0125-9326
VL - 54
SP - 567
EP - 573
JO - Acta medica Indonesiana
JF - Acta medica Indonesiana
IS - 4
ER -