Diagnostic challenge in a patient presenting with ascites and hypergammaglobulinemia

Syifa Mustika, Mirza Zaka Pratama, Cosmas Rinaldi Adithya Lesmana

Research output: Contribution to journalArticlepeer-review

Abstract

Ascites is defined as the accumulation of intra-peritoneal fluid that can be caused by several diseases. We described a 47-year-old female presenting with low serum-ascites albumin gradient (SAAG) and a markedly high level of serum globulin. Serum protein electrophoresis revealed an M spike in the gamma region. Other laboratory results showed a marked increase in aspartate aminotransferase and alanine aminotransferase and predominantly conjugated hyperbilirubinemia without a sign of dilatation of bile ducts from abdominal ultrasonography examination. Furthermore, the follow-up showed a positive result for the anti-nuclear antibody test. The patient was assessed with autoimmune hepatitis, and the cause of ascites was suggested from portal hypertension although the level of SAAG was low. The ascites condition got improved after salt restriction, diuretics treatment, and abdominal paracentesis. However, the patient passed away because of the intracranial hemorrhage as a result of prolonged INR and APTT due to liver failure.

Original languageEnglish
Pages (from-to)810-818
Number of pages9
JournalCase Reports in Gastroenterology
Volume15
Issue number3
DOIs
Publication statusPublished - 21 Sep 2021

Keywords

  • Ascites
  • Autoimmune hepatitis
  • Hypergammaglobulinemia

Fingerprint

Dive into the research topics of 'Diagnostic challenge in a patient presenting with ascites and hypergammaglobulinemia'. Together they form a unique fingerprint.

Cite this