Diagnosis and treatment of Langerhans Cell Histiocytosis with bone lesion in pediatric patient: A case report

Achmad Fauzi Kamal, Andi Praja Wira Yudha Luthfi

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© 2019 The Author(s) Background: Langerhans cell histiocytosis (LCH) is a rare group of disorders without a well understood etiology. Known formerly as histiocytosis X, the disease has a wide spectrum of clinical presentations, including eosinophilic granuloma (solitary bone lesion), diabetes insipidus, and exophthalmos. Many of these patients initially present to orthopaedic surgeons, and misdiagnosis is frequent. Methods: We deliver a case of a 10-month-old boy who consulted to our department. Previously misdiagnosed as a Kawasaki syndrome, TORCH, and osteomyelitis. He had undergone several examinations and had been discussed in clinocipathological conference (CPC) to narrow down the diagnosis. Result: After serial examinations, the diagnosis of Langerhans Cell Histiocytosis was confirmed and chemotherapy was initiated. And after 6 cycles of chemotherapy, with 1-week interval of each therapy, the clinical appearance of this patient significantly improved. Conclusion: Despite major advances in our understanding and management of LCH, it remains one of the most challenging diagnoses for the orthopedic surgeon. By doing a comprehensive examination, it is possible to narrowing down the diagnosis and planning the accurate treatment.
Original languageEnglish
Pages (from-to)102-109
Number of pages8
JournalAnnals of Medicine and Surgery
Publication statusPublished - 1 Sep 2019


  • Bone lesion
  • Case report
  • Langerhans cell hystiocytosis


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