Diagnosing peripheral neuropathy in South-East Asia: A focus on diabetic neuropathy

Rayaz A. Malik, Aimee Andag-Silva, Charungthai Dejthevaporn, Manfaluthy Hakim, Jasmine S. Koh, Rizaldy Pinzon, Norlela Sukor, Ka Sing Wong

Research output: Contribution to journalReview articlepeer-review

8 Citations (Scopus)


Burning and stabbing pain in the feet and lower limbs can have a significant impact on the activities of daily living, including walking, climbing stairs and sleeping. Peripheral neuropathy in particular is often misdiagnosed or underdiagnosed because of a lack of awareness amongst both patients and physicians. Furthermore, crude screening tools, such as the 10-g monofilament, only detect advanced neuropathy and a normal test will lead to false reassurance of those with small fiber mediated painful neuropathy. The underestimation of peripheral neuropathy is highly prevalent in the South-East Asia region due to a lack of consensus guidance on routine screening and diagnostic pathways. Although neuropathy as a result of diabetes is the most common cause in the region, other causes due to infections (human immunodeficiency virus, hepatitis B or C virus), chronic inflammatory demyelinating polyneuropathy, drug-induced neuropathy (cancer chemotherapy, antiretrovirals and antituberculous drugs) and vitamin deficiencies (vitamin B1, B6, B12, D) should be actively excluded.

Original languageEnglish
Pages (from-to)1097-1103
Number of pages7
JournalJournal of Diabetes Investigation
Issue number5
Publication statusPublished - 1 Sep 2020


  • Diagnosis
  • Peripheral neuropathy
  • South-East Asia


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