TY - JOUR
T1 - Diagnosing metabolic syndrome in a multi-ethnic country
T2 - is an ethnic-specific cut-off point of waist circumference needed?
AU - Tahapary, Dicky L.
AU - Harbuwono, Dante S.
AU - Yunir, Em
AU - Soewondo, Pradana
N1 - Funding Information:
This research was supported by Pintermidi Grant from Universitas Indonesia with contract number 1908/UN2.R3.1/HKP.05.00/2019. The authors would like to thank Melly Kristanti and Ninik Maris Saragih for their technical helps in preparing this manuscript. The authors would also like to thank Ekowati Rahajeng from The National Institute and Health Research and Development, Ministry of Health Republic of Indonesia.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The definition of Metabolic Syndrome (MS) required an ethnic-specific cut-off point for waist circumference (WC). We aim to assess the optimal ethnic-specific WC cut-off point for MS in Indonesia, a multi-ethnic country. Three population-based studies in Indonesia were included for analysis [Flores (n = 1227, Floresian), Depok (n = 904, Sundanese), and Jakarta (n = 1574, Javanese)]. All subjects were 25–65 years old. The receiver operator characteristic curve analysis and Youden index method was used to determine the optimal cut-offs of WC to predict two or more risk factors of MS. In Flores, the cut-offs were 80 cm (Sensitivity and Specificity, AUC, 84% and 73%, 0.86) and 77 cm (86% and 68%, 0.85), for men and women, respectively. While in Depok, the values were 87 cm (87% and 67%, 0.85) and 79 cm (94% and 54%, 0.79), for men and women, respectively. While in Jakarta, the values were 83 cm (92% and 60%, 0.85) and 81 cm (84% and 60%, 0.77), for men and women, respectively. The optimal WC cut-off values for MS were different in those three ethnicities, and in general were lower than the currently used cut-off points for Asian population.
AB - The definition of Metabolic Syndrome (MS) required an ethnic-specific cut-off point for waist circumference (WC). We aim to assess the optimal ethnic-specific WC cut-off point for MS in Indonesia, a multi-ethnic country. Three population-based studies in Indonesia were included for analysis [Flores (n = 1227, Floresian), Depok (n = 904, Sundanese), and Jakarta (n = 1574, Javanese)]. All subjects were 25–65 years old. The receiver operator characteristic curve analysis and Youden index method was used to determine the optimal cut-offs of WC to predict two or more risk factors of MS. In Flores, the cut-offs were 80 cm (Sensitivity and Specificity, AUC, 84% and 73%, 0.86) and 77 cm (86% and 68%, 0.85), for men and women, respectively. While in Depok, the values were 87 cm (87% and 67%, 0.85) and 79 cm (94% and 54%, 0.79), for men and women, respectively. While in Jakarta, the values were 83 cm (92% and 60%, 0.85) and 81 cm (84% and 60%, 0.77), for men and women, respectively. The optimal WC cut-off values for MS were different in those three ethnicities, and in general were lower than the currently used cut-off points for Asian population.
UR - http://www.scopus.com/inward/record.url?scp=85086168808&partnerID=8YFLogxK
U2 - 10.1038/s41387-020-0123-8
DO - 10.1038/s41387-020-0123-8
M3 - Article
C2 - 32513949
AN - SCOPUS:85086168808
SN - 2044-4052
VL - 10
JO - Nutrition and Diabetes
JF - Nutrition and Diabetes
IS - 1
M1 - 19
ER -
