Development of Electrochemical Lactate Biosensor: A Review

Hanif Tri Hartanto; Nurul Intan; Basari Basari; Siti Fauziyah Rahman

doi:10.1063/5.0198639

Development of Electrochemical Lactate Biosensor: A Review

Hanif Tri Hartanto, Nurul Intan, Basari Basari, Siti Fauziyah Rahman

Department of Electrical Engineering

Research output: Contribution to journal › Conference article › peer-review

Abstract

Due to the lack of early-stage symptoms, diabetes mellitus is known as the "silent killer". The prevalence of diabetes mellitus is significant and will continue to rise annually. Metformin is one of the treatments offered to people with diabetes mellitus. This medicine may lower blood glucose concentrations. In addition to the advantages of metformin, it causes lactic acidosis and can cause metformin-related lactic acidosis (MALA), which is associated with a mortality rate of 30-50%. This study discusses the determination methods of lactic acid levels in saliva samples of type 2 diabetes mellitus using an electrochemical biosensor. A review of a working electrode, enzyme immobilization methods, sample, the limit of detection, linear range, and stability of lactic acid biosensor.

Original language	English
Article number	110007
Journal	AIP Conference Proceedings
Volume	3080
Issue number	1
DOIs	https://doi.org/10.1063/5.0198639
Publication status	Published - 7 Mar 2024
Event	15th Asian Congress on Biotechnology in conjunction with the 7th International Symposium on Biomedical Engineering, ACB-ISBE 2022 - Bali, Indonesia Duration: 2 Oct 2022 → 6 Oct 2022

Keywords

biosensor
diabetes mellitus
electrochemical
lactate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1063/5.0198639

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title = "Development of Electrochemical Lactate Biosensor: A Review",

abstract = "Due to the lack of early-stage symptoms, diabetes mellitus is known as the {"}silent killer{"}. The prevalence of diabetes mellitus is significant and will continue to rise annually. Metformin is one of the treatments offered to people with diabetes mellitus. This medicine may lower blood glucose concentrations. In addition to the advantages of metformin, it causes lactic acidosis and can cause metformin-related lactic acidosis (MALA), which is associated with a mortality rate of 30-50%. This study discusses the determination methods of lactic acid levels in saliva samples of type 2 diabetes mellitus using an electrochemical biosensor. A review of a working electrode, enzyme immobilization methods, sample, the limit of detection, linear range, and stability of lactic acid biosensor.",

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T2 - 15th Asian Congress on Biotechnology in conjunction with the 7th International Symposium on Biomedical Engineering, ACB-ISBE 2022

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AU - Intan, Nurul

AU - Basari, Basari

AU - Rahman, Siti Fauziyah

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N2 - Due to the lack of early-stage symptoms, diabetes mellitus is known as the "silent killer". The prevalence of diabetes mellitus is significant and will continue to rise annually. Metformin is one of the treatments offered to people with diabetes mellitus. This medicine may lower blood glucose concentrations. In addition to the advantages of metformin, it causes lactic acidosis and can cause metformin-related lactic acidosis (MALA), which is associated with a mortality rate of 30-50%. This study discusses the determination methods of lactic acid levels in saliva samples of type 2 diabetes mellitus using an electrochemical biosensor. A review of a working electrode, enzyme immobilization methods, sample, the limit of detection, linear range, and stability of lactic acid biosensor.

AB - Due to the lack of early-stage symptoms, diabetes mellitus is known as the "silent killer". The prevalence of diabetes mellitus is significant and will continue to rise annually. Metformin is one of the treatments offered to people with diabetes mellitus. This medicine may lower blood glucose concentrations. In addition to the advantages of metformin, it causes lactic acidosis and can cause metformin-related lactic acidosis (MALA), which is associated with a mortality rate of 30-50%. This study discusses the determination methods of lactic acid levels in saliva samples of type 2 diabetes mellitus using an electrochemical biosensor. A review of a working electrode, enzyme immobilization methods, sample, the limit of detection, linear range, and stability of lactic acid biosensor.

KW - biosensor

KW - diabetes mellitus

KW - electrochemical

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Y2 - 2 October 2022 through 6 October 2022

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Development of Electrochemical Lactate Biosensor: A Review

Abstract

Keywords

UN SDGs

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