Development and validation of an analytical method for the determination of methylisothiazolinone and methylchloroisothiazolinone in cosmetic products using matrix solid-phase dispersion coupled to gas chromatography-mass spectrometry

Nurina Prapurandina, Harmita Harmita, Herman Suryadi

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This study was to develop the first simultaneous method for quantification of MI and MCI by using matrix solid-phase dispersion (MSPD) as an extraction technique followed by gas chromatography-tandem mass spectrometry (GC-MS) in cosmetic products to support that law enforcement. Methods: The MI and MCI were extracted from the cosmetic sample by using matrix solid-phase dispersion technique with alumina as solid sorbent and ethyl acetate as eluent. After being isolated, MI and MCI from the samples were analyzed using GC-MS equipped with DB-5MS capillary column. Results: The validated method for both leave-on and rinse-off cosmetic showed that MI and MCI recoveries were between 97.87-103.15 %, relative standard deviation (RSD) values were lower than 11%, and limit of quantitation (LOQ) values for the leave-on product were 0.96 µg/ml and 1.95 µg/ml and for rinse-off products were 0.56 µg/ml and 1.49 µg/ml for MI and MCI, respectively. Conclusion: This purposed analytical method for determining MI and MCI in cosmetic products using MSPD-GC-MS complies with the validation acceptance criteria.

Original languageEnglish
Pages (from-to)140-147
Number of pages8
JournalInternational Journal of Applied Pharmaceutics
Volume13
Issue number2
DOIs
Publication statusPublished - 2021

Keywords

  • Gas chromatography-mass spectrometry
  • Matrix solid-phase dispersion
  • Methylchloroisothiazolinone
  • Methylisothiazolinone
  • Validation

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