Determinants of cognitive health in Indonesian HIV patients beginning antiretroviral therapy

Riwanti Estiasari, Silvia Lee, Setia Pramana, Samsuridjal Djauzi, Patricia Price, IBNU AGUS ARIYANTO

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Cognitive impairment has been described in people living with HIV and stable on antiretroviral therapy (ART), but has not been monitored in young adults beginning ART with a high burden of cytomegalovirus. We recruited 80 subjects beginning ART with < 200 CD4 T cells/μL in Jakarta, Indonesia. Cognitive function (Z-scores) began low but improved on ART, stabilizing after 6 months with improvements in all domains except memory function. The burden of cytomegalovirus persisting on ART (assessed via antibody levels) correlated inversely with Z-scores (notably memory function) at baseline. In linear mixed models, improvements in Z-scores were influenced by age, education, and CD4 T cell counts.

Original languageEnglish
Pages (from-to)32-40
Number of pages9
JournalJournal of NeuroVirology
Volume26
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Antiretroviral therapy
  • CMV
  • HIV
  • Neurocognitive assessment

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