Determinants of cognitive health in Indonesian HIV patients beginning antiretroviral therapy

Riwanti Estiasari, Ibnu Aryanto, Silvia Lee, Setia Pramana, Samsuridjal Djauzi, Patricia Price

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Cognitive impairment has been described in people living with HIV and stable on antiretroviral therapy (ART), but has not been monitored in young adults beginning ART with a high burden of cytomegalovirus. We recruited 80 subjects beginning ART with < 200 CD4 T cells/μL in Jakarta, Indonesia. Cognitive function (Z-scores) began low but improved on ART, stabilizing after 6 months with improvements in all domains except memory function. The burden of cytomegalovirus persisting on ART (assessed via antibody levels) correlated inversely with Z-scores (notably memory function) at baseline. In linear mixed models, improvements in Z-scores were influenced by age, education, and CD4 T cell counts.

Original languageEnglish
JournalJournal of NeuroVirology
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Antiretroviral therapy
  • CMV
  • HIV
  • Neurocognitive assessment

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