Determinants of cognitive health in Indonesian HIV patients beginning antiretroviral therapy

Riwanti Estiasari; Silvia Lee; Setia Pramana; Samsuridjal Djauzi; Patricia Price; IBNU AGUS ARIYANTO

doi:10.1007/s13365-019-00787-2

Determinants of cognitive health in Indonesian HIV patients beginning antiretroviral therapy

Riwanti Estiasari, Silvia Lee, Setia Pramana, Samsuridjal Djauzi, Patricia Price, IBNU AGUS ARIYANTO

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Cognitive impairment has been described in people living with HIV and stable on antiretroviral therapy (ART), but has not been monitored in young adults beginning ART with a high burden of cytomegalovirus. We recruited 80 subjects beginning ART with < 200 CD4 T cells/μL in Jakarta, Indonesia. Cognitive function (Z-scores) began low but improved on ART, stabilizing after 6 months with improvements in all domains except memory function. The burden of cytomegalovirus persisting on ART (assessed via antibody levels) correlated inversely with Z-scores (notably memory function) at baseline. In linear mixed models, improvements in Z-scores were influenced by age, education, and CD4 T cell counts.

Original language	English
Pages (from-to)	32-40
Number of pages	9
Journal	Journal of NeuroVirology
Volume	26
Issue number	1
DOIs	https://doi.org/10.1007/s13365-019-00787-2
Publication status	Published - 1 Jan 2019

Keywords

Antiretroviral therapy
CMV
HIV
Neurocognitive assessment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13365-019-00787-2

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abstract = "Cognitive impairment has been described in people living with HIV and stable on antiretroviral therapy (ART), but has not been monitored in young adults beginning ART with a high burden of cytomegalovirus. We recruited 80 subjects beginning ART with < 200 CD4 T cells/μL in Jakarta, Indonesia. Cognitive function (Z-scores) began low but improved on ART, stabilizing after 6 months with improvements in all domains except memory function. The burden of cytomegalovirus persisting on ART (assessed via antibody levels) correlated inversely with Z-scores (notably memory function) at baseline. In linear mixed models, improvements in Z-scores were influenced by age, education, and CD4 T cell counts.",

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AU - Pramana, Setia

AU - Djauzi, Samsuridjal

AU - Price, Patricia

AU - ARIYANTO, IBNU AGUS

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N2 - Cognitive impairment has been described in people living with HIV and stable on antiretroviral therapy (ART), but has not been monitored in young adults beginning ART with a high burden of cytomegalovirus. We recruited 80 subjects beginning ART with < 200 CD4 T cells/μL in Jakarta, Indonesia. Cognitive function (Z-scores) began low but improved on ART, stabilizing after 6 months with improvements in all domains except memory function. The burden of cytomegalovirus persisting on ART (assessed via antibody levels) correlated inversely with Z-scores (notably memory function) at baseline. In linear mixed models, improvements in Z-scores were influenced by age, education, and CD4 T cell counts.

AB - Cognitive impairment has been described in people living with HIV and stable on antiretroviral therapy (ART), but has not been monitored in young adults beginning ART with a high burden of cytomegalovirus. We recruited 80 subjects beginning ART with < 200 CD4 T cells/μL in Jakarta, Indonesia. Cognitive function (Z-scores) began low but improved on ART, stabilizing after 6 months with improvements in all domains except memory function. The burden of cytomegalovirus persisting on ART (assessed via antibody levels) correlated inversely with Z-scores (notably memory function) at baseline. In linear mixed models, improvements in Z-scores were influenced by age, education, and CD4 T cell counts.

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Determinants of cognitive health in Indonesian HIV patients beginning antiretroviral therapy

Abstract

Keywords

UN SDGs

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