TY - JOUR
T1 - Determinants of circulating soluble leptin receptor and free leptin index in indonesian pre-pubertal obese male children
T2 - A preliminary cross-sectional study
AU - Hendarto, Aryono
AU - Nagrani, Dimple G.
AU - Meiliana, Anna
AU - Sastroasmoro, Sudigdo
AU - Sjarif, Damayanti R.
N1 - Publisher Copyright:
© 2020 by The Korean Society of Pediatric Gastroenterology
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Purpose: This study aimed to investigate the clinical and metabolic determinants of circulating soluble leptin receptor (CSLR) and free leptin index (FLI) in pre-pubertal obese male children. Methods: We conducted a preliminary cross-sectional study at three tertiary hospitals and one public primary school. Eighty obese male children without growth and developmental abnormalities aged 5-9 years were recruited. In these children, obesity was solely caused by excessive food intake, and not by acute illness, medications, endocrine abnormalities, or any syndrome. Body mass index (BMI), body fat mass, carbohydrate intake, fat intake, high density lipoprotein cholesterol level, low density lipoprotein cholesterol level, triglyceride level, and Homeostatic Model Assessment for Insulin Resistance are the potential determinants for leptin regulation, which is represented by CSLR level and FLI. Results: Carbohydrate was the main source of energy. BMI and body fat mass had negative weak correlation with CSLR and positive weak correlation with FLI. Furthermore, carbohydrate intake was found to be independently associated with CSLR based on the results of the multiple linear regression analysis. Following an increase in carbohydrate intake, CSLR level decreased progressively without any negative peak. Conclusion: Leptin regulation in prepubertal obese male children is associated with body composition and dietary intake. Carbohydrate intake is useful for predicting CSLR. Lipid profiles and insulin resistance are not related to both CSLR and FLI. Treatment and prevention of leptin resistance in obese children should focus on reducing BMI, fat mass, and carbohydrate intake.
AB - Purpose: This study aimed to investigate the clinical and metabolic determinants of circulating soluble leptin receptor (CSLR) and free leptin index (FLI) in pre-pubertal obese male children. Methods: We conducted a preliminary cross-sectional study at three tertiary hospitals and one public primary school. Eighty obese male children without growth and developmental abnormalities aged 5-9 years were recruited. In these children, obesity was solely caused by excessive food intake, and not by acute illness, medications, endocrine abnormalities, or any syndrome. Body mass index (BMI), body fat mass, carbohydrate intake, fat intake, high density lipoprotein cholesterol level, low density lipoprotein cholesterol level, triglyceride level, and Homeostatic Model Assessment for Insulin Resistance are the potential determinants for leptin regulation, which is represented by CSLR level and FLI. Results: Carbohydrate was the main source of energy. BMI and body fat mass had negative weak correlation with CSLR and positive weak correlation with FLI. Furthermore, carbohydrate intake was found to be independently associated with CSLR based on the results of the multiple linear regression analysis. Following an increase in carbohydrate intake, CSLR level decreased progressively without any negative peak. Conclusion: Leptin regulation in prepubertal obese male children is associated with body composition and dietary intake. Carbohydrate intake is useful for predicting CSLR. Lipid profiles and insulin resistance are not related to both CSLR and FLI. Treatment and prevention of leptin resistance in obese children should focus on reducing BMI, fat mass, and carbohydrate intake.
KW - Body fat mass
KW - Body mass index
KW - Circulating soluble leptin receptor
KW - Diet
KW - Free leptin index
KW - Insulin resistance
KW - Lipid
UR - http://www.scopus.com/inward/record.url?scp=85082946666&partnerID=8YFLogxK
U2 - 10.5223/pghn.2020.23.2.163
DO - 10.5223/pghn.2020.23.2.163
M3 - Article
AN - SCOPUS:85082946666
SN - 2234-8646
VL - 23
JO - Pediatric Gastroenterology, Hepatology and Nutrition
JF - Pediatric Gastroenterology, Hepatology and Nutrition
IS - 2
M1 - 163
ER -