Determinants of circulating soluble leptin receptor and free leptin index in indonesian pre-pubertal obese male children: A preliminary cross-sectional study

Aryono Hendarto, Dimple G. Nagrani, Anna Meiliana, Sudigdo Sastroasmoro, Damayanti R. Sjarif

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: This study aimed to investigate the clinical and metabolic determinants of circulating soluble leptin receptor (CSLR) and free leptin index (FLI) in pre-pubertal obese male children. Methods: We conducted a preliminary cross-sectional study at three tertiary hospitals and one public primary school. Eighty obese male children without growth and developmental abnormalities aged 5-9 years were recruited. In these children, obesity was solely caused by excessive food intake, and not by acute illness, medications, endocrine abnormalities, or any syndrome. Body mass index (BMI), body fat mass, carbohydrate intake, fat intake, high density lipoprotein cholesterol level, low density lipoprotein cholesterol level, triglyceride level, and Homeostatic Model Assessment for Insulin Resistance are the potential determinants for leptin regulation, which is represented by CSLR level and FLI. Results: Carbohydrate was the main source of energy. BMI and body fat mass had negative weak correlation with CSLR and positive weak correlation with FLI. Furthermore, carbohydrate intake was found to be independently associated with CSLR based on the results of the multiple linear regression analysis. Following an increase in carbohydrate intake, CSLR level decreased progressively without any negative peak. Conclusion: Leptin regulation in prepubertal obese male children is associated with body composition and dietary intake. Carbohydrate intake is useful for predicting CSLR. Lipid profiles and insulin resistance are not related to both CSLR and FLI. Treatment and prevention of leptin resistance in obese children should focus on reducing BMI, fat mass, and carbohydrate intake.

Original languageEnglish
Article number163
JournalPediatric Gastroenterology, Hepatology and Nutrition
Volume23
Issue number2
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • Body fat mass
  • Body mass index
  • Circulating soluble leptin receptor
  • Diet
  • Free leptin index
  • Insulin resistance
  • Lipid

Fingerprint Dive into the research topics of 'Determinants of circulating soluble leptin receptor and free leptin index in indonesian pre-pubertal obese male children: A preliminary cross-sectional study'. Together they form a unique fingerprint.

Cite this