Universities have an important role in enhancing the education of a nation, which aligned with efforts to create qualified graduates. In relation to this circumstance, universities generally establish several standards (apart from the national standards established by the Ministry) in their academic systems such as standard of competency, study allocation for each semester, teaching and learning processes, teaching period and any other related standards depend on faculty and/department within the universities. However, those established standards create the amount of demand and/study burden, particularly for students. This paper aims to develop a design framework and present the responsible factors that related to academic systems, by the questionnaires that are designed for monitoring the effect of the academic systems on student burnout during their study. This paper focusing on the relation of student burnout toward the academic system which is analyzed with Partial Least Square (PLS) method. It is expected that the output framework from this paper will contribute in evaluating the academic system on higher education and can be a guide for developing a better academic system within the department university hence improving the quality of student outcomes and prevent burnout.