Design, synthesis, and cytotoxicity evaluation of novel open-chain analogues of antimycin A₃ as potential anti-colorectal cancer agents

Keyphrases

• Cytotoxicity Test 100%
• Anti-colorectal Cancer 100%
• Design Evaluation 100%
• Antimycin A3 100%
• Cancer Agent 100%
• Open Chain 100%
• Synthetic Evaluation 100%
• HCT116 Cells 33%
• Stereocenters 33%
• Hydroxyl Group 16%
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide 16%
• Colorectal Cancer 16%
• Esterification 16%
• Cytotoxicity 16%
• Good Yield 16%
• Anticancer Activity 16%
• Amidation 16%
• Inhibitory Concentration 16%
• Cell Proliferation Assay 16%
• Threonine 16%
• Side Chain 16%
• Ester Group 16%
• Sharpless Asymmetric Dihydroxylation 16%
• Hydroxylated 16%
• Cancer Activity 16%
• Dilactones 16%
• Analog Synthesis 16%

Chemistry

• Esterification 100%
• Hydroxyl Group 100%
• Sharpless Asymmetric Dihydroxylation 100%
• Inhibitory Concentration 100%
• 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium Bromide 100%
• L-Threonine 100%
• amidation 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Carcinogen 100%
• Citrinin 100%
• Colorectal Carcinoma 100%
• Cytotoxicity 100%
• Malignant Neoplasm 16%
• Hydroxyl Group 16%
• 3 (4,5 Dimethyl 2 Thiazolyl) 2,5 Diphenyltetrazolium Bromide 16%
• IC50 16%
• Threonine 16%