Design, synthesis, and antioxidant evaluation of monocarbonyl curcumin analogues tethered 1,2,3-triazole scaffold

Bayu Ardiansah, Muhammad Ridho Hardhani, Decky Duem Syaban Ridho Putera, Tuti Wukirsari, Antonius Herry Cahyana, Jing Wen Jia, Md Musawwer Khan

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Half- and full-skeletal of curcumin analogues containing mono- and bis-triazole scaffold have been successfully synthesized from simple aromatic aldehydes. The route is including aldol condensation, propargylation, and then continued with azide-alkyne [3 + 2] cycloaddition to afford the triazoled curcumin analogues 3a-3e. The structures of the synthesized compounds have been established on the basis of FTIR, 1H and 13C NMR, and HRMS. The antioxidant activity of all final compounds has been screened. All compounds were found to be moderate against DPPH radical, and 3b was denoted as the most active product with inhibition of 32.04 ± 0.30% at 100 ppm.

Original languageEnglish
Article number100425
JournalCase Studies in Chemical and Environmental Engineering
Volume8
DOIs
Publication statusPublished - Dec 2023

Keywords

  • 1,2,3-Triazole
  • Antioxidant
  • Azide-alkyne cycloaddition
  • Hybrid compounds
  • Monocarbonyl analogues of curcumin

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