TY - JOUR
T1 - Design, synthesis, and antioxidant evaluation of monocarbonyl curcumin analogues tethered 1,2,3-triazole scaffold
AU - Ardiansah, Bayu
AU - Hardhani, Muhammad Ridho
AU - Putera, Decky Duem Syaban Ridho
AU - Wukirsari, Tuti
AU - Cahyana, Antonius Herry
AU - Jia, Jing Wen
AU - Khan, Md Musawwer
N1 - Funding Information:
This work was fully funded by the Directorate of Research and Development , Universitas Indonesia through Hibah Publikasi International Terindeks (PUTI Q1 Research Grant) with contract No. NKB-474/UN2.RST/HKP.05.00/2022 . The authors would like to thank Ms. Pratiwi Puji Lestari, M.Si. (ILRC, UI) for recording NMR spectra and Mr. Azhar Darlan (Forensic Laboratory Center, POLRI) for measuring HRMS spectra.
Publisher Copyright:
© 2023 The Authors
PY - 2023/12
Y1 - 2023/12
N2 - Half- and full-skeletal of curcumin analogues containing mono- and bis-triazole scaffold have been successfully synthesized from simple aromatic aldehydes. The route is including aldol condensation, propargylation, and then continued with azide-alkyne [3 + 2] cycloaddition to afford the triazoled curcumin analogues 3a-3e. The structures of the synthesized compounds have been established on the basis of FTIR, 1H and 13C NMR, and HRMS. The antioxidant activity of all final compounds has been screened. All compounds were found to be moderate against DPPH radical, and 3b was denoted as the most active product with inhibition of 32.04 ± 0.30% at 100 ppm.
AB - Half- and full-skeletal of curcumin analogues containing mono- and bis-triazole scaffold have been successfully synthesized from simple aromatic aldehydes. The route is including aldol condensation, propargylation, and then continued with azide-alkyne [3 + 2] cycloaddition to afford the triazoled curcumin analogues 3a-3e. The structures of the synthesized compounds have been established on the basis of FTIR, 1H and 13C NMR, and HRMS. The antioxidant activity of all final compounds has been screened. All compounds were found to be moderate against DPPH radical, and 3b was denoted as the most active product with inhibition of 32.04 ± 0.30% at 100 ppm.
KW - 1,2,3-Triazole
KW - Antioxidant
KW - Azide-alkyne cycloaddition
KW - Hybrid compounds
KW - Monocarbonyl analogues of curcumin
UR - http://www.scopus.com/inward/record.url?scp=85166313724&partnerID=8YFLogxK
U2 - 10.1016/j.cscee.2023.100425
DO - 10.1016/j.cscee.2023.100425
M3 - Article
AN - SCOPUS:85166313724
SN - 2666-0164
VL - 8
JO - Case Studies in Chemical and Environmental Engineering
JF - Case Studies in Chemical and Environmental Engineering
M1 - 100425
ER -