Design and rationale for the treatment effects of provisional side branch stenting and DK crush stenting techniques in patients with unprotected distal left main coronary artery bifurcation lesions (DKCRUSH V) Trial

Shao Liang Chen, Ya Ling Han, Liang Long Chen, Chun Guang Qiu, Tie Min Jiang, Ling Tao, Hesong Zeng, Li Li, Yong Xia, Chuanyu Gao, Teguh Santoso Sukamto, Chootopol Paiboon, Yan wang, Tak W. Kwan, Jue Jie Zhang, Fei Ye, Nai Liang Tian, Zhi Zhong Liu, Song Lin, Cheng Zhi LuShangyu Wen, Lang Hong, Qi Zhang, Imad Sheiban, Yawei Xu, Lefeng Wang, Shao Yu Chen, Zhanquan Li, Guanchang Cheng, Lianqun Cui

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background Provisional stenting (PS) is effective for great majority of patients with coronary bifurcation lesions. Double kissing (DK) crush approach demonstrated significant reduction of target lesion revascularization (TLR) for patients with more complex bifurcation lesion when compared with PS. Furthermore, DK crush technique was associated with lower rate of composite major adverse cardiac event (MACE), revascularization and stent thrombosis (ST) for patients with unprotected distal left main coronary artery bifurcation lesions (ULMb), compared to culotte stenting approach. The DKCRUSH V trial is designed to elucidate the benefits of DK crush over PS in patients with ULMb. Study design DKCRUSH V is a randomized, prospective, multinational clinical trial designed to evaluate the efficacy and safety of DK crush over PS for patients with ULMb. Subjects with Medina 1,1,1 or 0,1,1 ULMb will be randomized in a 1:1 fashion to PS or DK crush. The primary endpoint is target lesion failure (TLF) including target vessel myocardial infarction, cardiac death and TLR. Other endpoints address individual event of primary endpoint, and target vessel revascularization. The safety objective is the ST. Recruitment began in January 2012 and was completed in December 2015; 484 patients were randomized. The trial will continue until at least 56 adjudicated primary endpoints occur. Conclusions The DKCRUSH V study is investigating if DK crush approach versus PS will reduce the incidence of TLF in patients with symptomatic ULMb.

Original languageEnglish
Pages (from-to)4-9
Number of pages6
JournalClinical Trials and Regulatory Science in Cardiology
Volume22
DOIs
Publication statusPublished - 1 Oct 2016

Keywords

  • Coronary artery
  • Double-kissing crush
  • Left main bifurcation lesions
  • Provisional side branch stenting

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