TY - JOUR
T1 - Descending Aorta Diameters as Predictor of Late Adverse Outcomes in Patients with Uncomplicated Type B Aortic Dissection
T2 - A Systematic Review and Meta-Analysis
AU - Nugraha, Raka Aldy
AU - Amshar, Mohamed
AU - Batubara, Edwin Adhi Darmawan
AU - Siddiq, Taofan
AU - Indriani, Suci
AU - Adiarto, Suko
N1 - Publisher Copyright:
© 2021
PY - 2022/3
Y1 - 2022/3
N2 - Background: A subset of patients with uncomplicated type B aortic dissection (uTBAD) has been shown to possess higher risk of experiencing late adverse outcomes. Therefore, we conducted an analysis to investigate the role of descending aorta diameters, including total descending aorta diameter and false lumen diameter, as predictor of late adverse outcomes in patients with uTBAD. Methods: A systematic search was performed through Pubmed, ClinicalKey, ScienceDirect, and Cochrane Library to identify relevant studies. Our primary outcome was the composite late adverse events following their first episode of hospitalization. All meta-analyses were performed using Review Manager version 5.4. Results: A total of 2,339 (male 68.8%) patients from a total of 15 cohorts were included in our analysis. During follow-up period, there were 655 (27.3%) and 149 (6.3%) cases of late adverse events and mortality, respectively. Patients with higher initial descending aorta diameter were at higher risk of developing late adverse events (RR 2.99 [2.60, 3.44]; P < 0.001) and mortality (RR 3.15 [2.34, 4.25]; P <0.001) throughout follow-up period. Maximum false lumen diameter at the initial presentation seemed to significantly be associated with late adverse events (RR 1.87 [1.46, 2.39]; P <0.001) but not with mortality (RR 2.55 [0.81-8.00; P = 0.11). Conclusion: Descending aorta diameters, particularly maximum initial descending aorta diameter, is a good and helpful predictor of late adverse outcomes in patients with uTBAD.
AB - Background: A subset of patients with uncomplicated type B aortic dissection (uTBAD) has been shown to possess higher risk of experiencing late adverse outcomes. Therefore, we conducted an analysis to investigate the role of descending aorta diameters, including total descending aorta diameter and false lumen diameter, as predictor of late adverse outcomes in patients with uTBAD. Methods: A systematic search was performed through Pubmed, ClinicalKey, ScienceDirect, and Cochrane Library to identify relevant studies. Our primary outcome was the composite late adverse events following their first episode of hospitalization. All meta-analyses were performed using Review Manager version 5.4. Results: A total of 2,339 (male 68.8%) patients from a total of 15 cohorts were included in our analysis. During follow-up period, there were 655 (27.3%) and 149 (6.3%) cases of late adverse events and mortality, respectively. Patients with higher initial descending aorta diameter were at higher risk of developing late adverse events (RR 2.99 [2.60, 3.44]; P < 0.001) and mortality (RR 3.15 [2.34, 4.25]; P <0.001) throughout follow-up period. Maximum false lumen diameter at the initial presentation seemed to significantly be associated with late adverse events (RR 1.87 [1.46, 2.39]; P <0.001) but not with mortality (RR 2.55 [0.81-8.00; P = 0.11). Conclusion: Descending aorta diameters, particularly maximum initial descending aorta diameter, is a good and helpful predictor of late adverse outcomes in patients with uTBAD.
UR - http://www.scopus.com/inward/record.url?scp=85121269565&partnerID=8YFLogxK
U2 - 10.1016/j.avsg.2021.10.033
DO - 10.1016/j.avsg.2021.10.033
M3 - Review article
AN - SCOPUS:85121269565
VL - 80
SP - 333
EP - 344
JO - Annals of Vascular Surgery
JF - Annals of Vascular Surgery
SN - 0890-5096
ER -