DENTINOGENESIS IMPERFEKTA : ASPEK GENETIKA MOLEKULAR, KLASIFIKASI DAN UPAYA PENANGGULANGANNYA

Elza Ibrahim, Surjadi, S. Mangoendjaja

Research output: Contribution to journalArticlepeer-review

Abstract

Dentinogenesis Imperfecta (DI) is a hereditary simple autosomal dominant disorder showing abnormalities in the dentin of developing teeth and occuring at a rate of about 1 in 8000 births affecting both primary and secondary dentitions. The expression of DI shows a high penetrance and a low mutation rate. Two main types of DI appear to exist: type 1 which is the defect associate with osteogenesis imperfecta, and type II which is the classical hereditary opalescent dentin. The formerly proposed DI type III appears to be only a modified expression of the same gene as in the classical DI type II. This paper reviews molecular genetic aspects of DI.

Original languageIndonesian
JournalJournal of Dentistry Indonesia
Publication statusPublished - 1999

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