The vaccine is a great discovery that is weak against a certain temperature. Storing it at the wrong temperature can damage the vaccine. Vaccines require cold chains in the supply chain that control the temperature and humidity of the vaccine to maintain its potential from the vaccine production process to the vaccine administration to the patient. Stakeholders must follow standard cold chain management procedures consistently. Due to the many risks that are surrounding it, risk management is necessary in order to run the supply chain efficiently. This study aims to provide a risk assessment in the vaccine supply chain in Indonesia with results to prioritize the risks. MCDM method, DEMATEL based ANP (DANP), was used to assess the risks. The relations among risks also discussed in this study. The results show that the five highest ranks of risks involve in Indonesia's vaccine supply chain are storage and warehousing, costs related to material supply, risk in planning production scheduling or product order planning, transportation cost, and competitive risk.