Delivery of Potential Drugs to The Colon: Challenges and Strategies

Raditya Iswandana, Kurnia Sari Setio Putri, Sekar Arum Larasati, Maxius Gunawan, Fathia Amalia Putri

Research output: Contribution to journalReview articlepeer-review

Abstract

Colon-targeted drug delivery systems have been exploited to treat local diseases in the colon, systemic delivery of protein and peptide, and chronotherapeutic drugs. However, the upper gastrointestinal tract restricts the effective delivery. Therefore, several strategies are needed for drugs targeted directly to the colon, such as pH-sensitive and enzyme-sensitive polymers, bacterially degradable polysaccharides, time-dependent polymers, as well as particulate systems. Variable physiological conditions of the gastrointestinal tract in individuals cause the combinations of these strategies to ensure colonic delivery of drugs. This review presents and discusses several potential drugs and the approaches used to design and develop colon-targeted drug delivery systems for medications with particular characteristics.

Original languageEnglish
Pages (from-to)307-332
Number of pages26
JournalIndonesian Journal of Pharmacy
Volume33
Issue number3
DOIs
Publication statusPublished - 2022

Keywords

  • active compound
  • challenges
  • colon
  • colon-targeted drug delivery systems
  • strategies

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