El extracto de bulbos de cebollas dayak (Eleutherine bulbosa (Mill.) Urb.) reduce la presión sanguínea en un modelo hipoestrogénico en ratas controlando el perfil lipídico

Translated title of the contribution: Dayak onions (Eleutherine bulbosa (Mill.) Urb.) bulbs extracts reduces blood pressure of hypoestrogen model rats by controlling lipids profile

Anton Bahtiar, Delvika Yessi Chumala

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To determine the effects of 70 % ethanolic extract of Eleutherine bulbosa (Mill.) L. bulbs contained naphtoquinone in blood pressure and lipids profile level of ovariectomized rats. Thin layer chromatography was performed to analyze the content of the Eleutherine bulbosa (Mill.) bulbs extracts using Chloroform: Methanol (7:1) as eluent. This study used white female Sprague-Dawley rats which were divided into 6 groups: SHAM and OVX, both given 0.5 % carboxymethyl cellulose; the positive control group that was given tamoxifen (0.36 mg/200 g B.W.); the three various of doses of extract namely dose 1, 2, and 3 that were given 8, 12, and 18 mg/200 g BW respectively on day 29 until 50. All groups were ovariectomized on day 1, except sham group. Measurement of blood pressure were performed on the day before ovariectomy using non-invasive tool CODA®; and on the second, third, and fourth weeks post-ovariectomy. Three weeks after treatment of hypoestrogen rats by the dose 18 mg/200 g B.W, Eleutherine bulbosa extracts could decrease the systolic blood pressure level to 28.06 %, the diastolic to 30.47 %. Lipid profile of Dose 3 also showed recovery of Triglyceride, LDL and also Total Cholesterol. Eleutherine bulbosa extracts could improve blood pressure of ovariectomized rats by controlling lipids profile level.

Translated title of the contributionDayak onions (Eleutherine bulbosa (Mill.) Urb.) bulbs extracts reduces blood pressure of hypoestrogen model rats by controlling lipids profile
Original languageSpanish
Pages (from-to)1016-1021
Number of pages6
JournalInternational Journal of Morphology
Volume36
Issue number3
DOIs
Publication statusPublished - 1 Sep 2018

Keywords

  • Blood pressure
  • Dayak onions
  • Eleutherinol
  • Hypoestrogen
  • Naphtoquinone

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