Cytotoxic activity of citronellyl caproate on murine leukemia (P388) cells

Galuh Widiyarti, Muhammad Hanafi, Soleh Kosela, Emil Budianto

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Citronellol is a monoterpene compound and has been known having antibacterial, antioxidant, antiinflamation, and anticancer activity. To increased activity, ester compound was synthesized from citronellol and caproic acid by using sodium hydroxyde as catalyst. Analysis of ester compound was carried out by TLC, IR, LC-MS, and NMR. Whilst analysis of in-vitro cytotoxic activity was carried out by BSLT and MTT methods against Artemia salina and murine leukemia (P388) cells, respectively. The result showed that citronellyl caproate was very active against Artemia salina with LC50 1.21 μg/mL and has potency as anti-leukemia cancer, indicated by IC50 10.63 μg/mL against murine leukemia (P388) cells.

Original languageEnglish
Pages (from-to)209-220
Number of pages12
JournalInternational Journal of Applied Chemistry
Issue number3
Publication statusPublished - 2016


  • Citronellol
  • Citronellyl caproate
  • Leukemia


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