TY - JOUR
T1 - Cytotoxic activity of citronellyl caproate on murine leukemia (P388) cells
AU - Widiyarti, Galuh
AU - Hanafi, Muhammad
AU - Kosela, Soleh
AU - Budianto, Emil
N1 - Publisher Copyright:
© Research India Publications.
PY - 2016
Y1 - 2016
N2 - Citronellol is a monoterpene compound and has been known having antibacterial, antioxidant, antiinflamation, and anticancer activity. To increased activity, ester compound was synthesized from citronellol and caproic acid by using sodium hydroxyde as catalyst. Analysis of ester compound was carried out by TLC, IR, LC-MS, and NMR. Whilst analysis of in-vitro cytotoxic activity was carried out by BSLT and MTT methods against Artemia salina and murine leukemia (P388) cells, respectively. The result showed that citronellyl caproate was very active against Artemia salina with LC50 1.21 μg/mL and has potency as anti-leukemia cancer, indicated by IC50 10.63 μg/mL against murine leukemia (P388) cells.
AB - Citronellol is a monoterpene compound and has been known having antibacterial, antioxidant, antiinflamation, and anticancer activity. To increased activity, ester compound was synthesized from citronellol and caproic acid by using sodium hydroxyde as catalyst. Analysis of ester compound was carried out by TLC, IR, LC-MS, and NMR. Whilst analysis of in-vitro cytotoxic activity was carried out by BSLT and MTT methods against Artemia salina and murine leukemia (P388) cells, respectively. The result showed that citronellyl caproate was very active against Artemia salina with LC50 1.21 μg/mL and has potency as anti-leukemia cancer, indicated by IC50 10.63 μg/mL against murine leukemia (P388) cells.
KW - Citronellol
KW - Citronellyl caproate
KW - Leukemia
UR - http://www.scopus.com/inward/record.url?scp=84977079435&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84977079435
SN - 0973-1792
VL - 12
SP - 209
EP - 220
JO - International Journal of Applied Chemistry
JF - International Journal of Applied Chemistry
IS - 3
ER -