TY - JOUR
T1 - CYP2A6 gene polymorphisms impact to nicotine metabolism
AU - Muliaty, Dewi
AU - Yusuf, Irawan
AU - Setiabudy, Rianto
AU - Wanandi, Septelia Inawati
N1 - Publisher Copyright:
© 2010, Faculty of Medicine, Universitas Indonesia. All rights reserved.
PY - 2010/2
Y1 - 2010/2
N2 - Nicotine is a major addictive compound in tobacco cigarette smoke. After being absorbed by the lung nicotine is rapidly metabolized and mainly inactivated to cotinine by hepatic cytochrome P450 2A6 (CYP2A6) enzyme. Genetic polymorphisms in CYP2A6 may play a role in smoking behavior and nicotine dependence. CYP2A6*1A is the wild type of the CYP2A6 gene which is associated with normal or extensive nicotine metabolism. In the CYP2A6 gene, several polymorphic alleles have been reported such as CYP2A6*4, CYP2A6*7, CYP2A6*9, and CYP2A6*10 which are related to decreasing nicotine metabolism activity. The variation of nicotine metabolism activity could alter nicotine plasma levels. Smokers need a certain level of nicotine in their brain and must smoke regularly because of nicotine’s short half-life; this increases the number of smoked cigarettes in extensive metabolizers. Meanwhile, in slow metabolizers, nicotine plasma level may increase and results in nicotine toxicity. This will eventually lower the risk of dependence.
AB - Nicotine is a major addictive compound in tobacco cigarette smoke. After being absorbed by the lung nicotine is rapidly metabolized and mainly inactivated to cotinine by hepatic cytochrome P450 2A6 (CYP2A6) enzyme. Genetic polymorphisms in CYP2A6 may play a role in smoking behavior and nicotine dependence. CYP2A6*1A is the wild type of the CYP2A6 gene which is associated with normal or extensive nicotine metabolism. In the CYP2A6 gene, several polymorphic alleles have been reported such as CYP2A6*4, CYP2A6*7, CYP2A6*9, and CYP2A6*10 which are related to decreasing nicotine metabolism activity. The variation of nicotine metabolism activity could alter nicotine plasma levels. Smokers need a certain level of nicotine in their brain and must smoke regularly because of nicotine’s short half-life; this increases the number of smoked cigarettes in extensive metabolizers. Meanwhile, in slow metabolizers, nicotine plasma level may increase and results in nicotine toxicity. This will eventually lower the risk of dependence.
KW - Cotinine
KW - Hepatic cytochrome P450 2A6
KW - Smoking behavior
UR - http://www.scopus.com/inward/record.url?scp=85008870998&partnerID=8YFLogxK
U2 - 10.13181/mji.v19i1.377
DO - 10.13181/mji.v19i1.377
M3 - Article
AN - SCOPUS:85008870998
SN - 0853-1773
VL - 19
SP - 46
EP - 51
JO - Medical Journal of Indonesia
JF - Medical Journal of Indonesia
IS - 1
ER -