Cyp1a1 gene polymorphism (6235 T/C) in head and neck cancer of an indonesian population

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Abstract

One of the genes that plays a role in the formation of cancer cells is CYP1A1 (cytochrome P450, family 1, subfamily A, polypeptide 1) CYP1A1 codes for enzymes that have an important role in activating or detoxifying carcinogenic elements in tobacco and other compounds. This study aimed to investigate the potential association of CYP1A1 gene polymorphism and the incidence of head and neck cancer (HNC) by comparing the polymorphism distribution in HNC patients and healthy controls of an Indonesian population. Polymerase Chain Reaction -Restriction Fragment length Polymorphism (PCR-RFLP) techniques with the MspI enzyme were used for genotyping of the single nucleotide polymorphisms (SNPs) of CYP1A1 (rs4646903) in HNC patients and healthy controls. The frequencies of the TT genotype were 34% for HNC and 30% for the healthy controls; CT was 56% for HNC and 66% for the healthy controls; homozygote CC was 10% for HNC and 4% for the healthy controls. There is no significant association of CYP1A1 gene polymorphisms (6236 T/C) between patients with HNC and healthy controls.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalJournal of International Dental and Medical Research
Volume10
Issue numberSpecialissue
Publication statusPublished - 1 Jan 2017

Keywords

  • CYP1A1 (6235 T/C)
  • Head and neck cancer
  • Indonesia
  • Polymorphism

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