TY - JOUR
T1 - Current Perspectives and Unmet Needs of Primary Immunodeficiency Care in Asia Pacific
AU - Leung, Daniel
AU - Chua, Gilbert T.
AU - Mondragon, Alric V.
AU - Zhong, Youjia
AU - Nguyen-Ngoc-Quynh, Le
AU - Imai, Kohsuke
AU - Vignesh, Pandiarajan
AU - Suratannon, Narissara
AU - Mao, Huawei
AU - Lee, Wen I.
AU - Kim, Yae Jean
AU - Chan, Godfrey C.F.
AU - Liew, Woei Kang
AU - Huong, Le Thi Minh
AU - Kanegane, Hirokazu
AU - Muktiarti, Dina
AU - Zhao, Xiaodong
AU - Santos-Ocampo, Fatima Johanna
AU - Latiff, Amir Hamzah Abdul
AU - Seger, Reinhard
AU - Ochs, Hans D.
AU - Singh, Surjit
AU - Lee, Pamela P.
AU - Lau, Yu Lung
N1 - Publisher Copyright:
© Copyright © 2020 Leung, Chua, Mondragon, Zhong, Nguyen-Ngoc-Quynh, Imai, Vignesh, Suratannon, Mao, Lee, Kim, Chan, Liew, Huong, Kanegane, Muktiarti, Zhao, Santos-Ocampo, Latiff, Seger, Ochs, Singh, Lee and Lau.
PY - 2020/8/13
Y1 - 2020/8/13
N2 - Background: The Asia Pacific Society for Immunodeficiencies (APSID) conducted nine primary immunodeficiency (PID) Schools in 5 years since inauguration to provide PID care training for early career physicians in Asia Pacific, a region with divergent needs in PID resources and training. Objective: To identify differences in PID patient care resource and training needs across Asia Pacific and propose a corresponding action plan. Methods: The Human Development Index (HDI) indicates the degree of socio-economic development in each country/region. Information related to investigations and learning issues were extracted from the abstracts and personal statements from all Schools and mapped onto resource and training needs. Correlations between HDI and country/region-specific parameters were tested by two-tailed Pearson correlation. Results: A total of 427 abstracts were received in nine Schools between 2015 and 2020, predominantly on immunodeficiencies affecting cellular and humoral immunity. Genetic confirmation was described in 61.8% of abstracts, and its absence negatively correlated with HDI (r = −0.696, p = 0.004). Essential immunologic and genetic tests were not available in 25.4 and 29.5% of abstracts, respectively, and their absence negatively correlated with HDI (r = −0.788, p < 0.001; r = −0.739, p = 0.002). HDI positively correlated with average testing level (r = 0.742, p = 0.002). Cases from medium-HDI countries/regions focused on learning how to investigate a patient for PIDs in cases of severe or atypical infections, whereas those from very-high-HDI countries/regions, from which most faculty members originated, listed hematopoietic stem cell transplantation and gene therapy, newborn screening, and research as learning issues more frequently. Conclusion: There are unique HDI-related PID resource and training needs in each country/region. APSID proposes HDI group-specific strategies to improve PID care and education in her member countries/regions. Further quantitative analysis of needs in PID care in Asia Pacific is needed for lobbying governments to increase their support for PID care and research.
AB - Background: The Asia Pacific Society for Immunodeficiencies (APSID) conducted nine primary immunodeficiency (PID) Schools in 5 years since inauguration to provide PID care training for early career physicians in Asia Pacific, a region with divergent needs in PID resources and training. Objective: To identify differences in PID patient care resource and training needs across Asia Pacific and propose a corresponding action plan. Methods: The Human Development Index (HDI) indicates the degree of socio-economic development in each country/region. Information related to investigations and learning issues were extracted from the abstracts and personal statements from all Schools and mapped onto resource and training needs. Correlations between HDI and country/region-specific parameters were tested by two-tailed Pearson correlation. Results: A total of 427 abstracts were received in nine Schools between 2015 and 2020, predominantly on immunodeficiencies affecting cellular and humoral immunity. Genetic confirmation was described in 61.8% of abstracts, and its absence negatively correlated with HDI (r = −0.696, p = 0.004). Essential immunologic and genetic tests were not available in 25.4 and 29.5% of abstracts, respectively, and their absence negatively correlated with HDI (r = −0.788, p < 0.001; r = −0.739, p = 0.002). HDI positively correlated with average testing level (r = 0.742, p = 0.002). Cases from medium-HDI countries/regions focused on learning how to investigate a patient for PIDs in cases of severe or atypical infections, whereas those from very-high-HDI countries/regions, from which most faculty members originated, listed hematopoietic stem cell transplantation and gene therapy, newborn screening, and research as learning issues more frequently. Conclusion: There are unique HDI-related PID resource and training needs in each country/region. APSID proposes HDI group-specific strategies to improve PID care and education in her member countries/regions. Further quantitative analysis of needs in PID care in Asia Pacific is needed for lobbying governments to increase their support for PID care and research.
KW - health resources
KW - immunology
KW - primary immunodeficiencies
KW - resource needs
KW - specialty training
KW - standard of care
UR - http://www.scopus.com/inward/record.url?scp=85089887512&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2020.01605
DO - 10.3389/fimmu.2020.01605
M3 - Article
AN - SCOPUS:85089887512
SN - 1664-3224
VL - 11
JO - Frontiers in Immunology
JF - Frontiers in Immunology
M1 - 1605
ER -
