Curcumin protects against failure to generate a transmembrane potential and protein aggregation of rat liver mitochondria induced by tert-butylhydroperoxides

Franciscus D. Suyatna, S. Susilowati, A. Setiawati

Research output: Contribution to journalArticle

Abstract

Curcumin, an active ingredient of curcuma plant has been thought to be beneficial in the treatment of liver diseases. In the previous studies, we have shown the protective effects of curcumin against lipid peroxidation and swelling of the rat liver mitochondrial preparation induced by tert-butylhydroperoxide (t-BuOOH). In the present study, the administration of t-BuOOH of 90 μM caused the mitochondria failed to generate a transmembrane potential (ψm). Of 3 doses of curcumin administered (0.5 μM, 2.5 μM dan 5.0 μM) the maximum protective effect against failure to generate a transmembrane potential caused by t-BuOOH was obtained by 2.5 μM of curcumin (79.13 ± 6.28%). Further, curcumin of 1000 μM could prevent protein aggregation formation caused by t-BuOOH in the electrophoretogram. This study shows the protective effects of curcumin against damaged of energy production system and protein of the mitochondria caused by t-BuOOH.

Original languageEnglish
Pages (from-to)139-145
Number of pages7
JournalMedical Journal of Indonesia
Volume16
Issue number3
DOIs
Publication statusPublished - 1 Jul 2007

Keywords

  • Curcumin
  • Mitochondria
  • Protein electrophoresis
  • T-BuOOH
  • Transmembrane potential

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