Curcumin isolation, synthesis and characterization of curcumin isoxazole derivative compound

N. Nurjanah, E. Saepudin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Curcumin, one of the curcuminoid constituents which derived from Curcuma longa, has been extensively used as a pharmacological agent. This study was started with extraction of the curcuminoid from Curcuma longa where extraction was carried out with two different solvents (dichloromethane and ethanol), followed by isolation of curcumin from the other two components of curcuminoid. The pure curcumin was converted to its isoxazole derivative with the addition of NH2OH·HCl. The reaction product was characterized using mass spectrometry, UV/Vis and FTIR spectrophotometry. Optimization of the extraction and synthesis shows that for the extraction ethanol was a better solvent than dichloromethane with 12.67 % yield. Temperature and optimization time for synthesis of curcumin isoxazole were 70 °C and 8 hours, respectively.

Original languageEnglish
Title of host publicationProceedings of the 4th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2018
EditorsTerry Mart, Djoko Triyono, Ivandini T. Anggraningrum
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419155
DOIs
Publication statusPublished - 4 Nov 2019
Event4th International Symposium on Current Progress in Mathematics and Sciences 2018, ISCPMS 2018 - Depok, Indonesia
Duration: 30 Oct 201831 Oct 2018

Publication series

NameAIP Conference Proceedings
Volume2168
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Symposium on Current Progress in Mathematics and Sciences 2018, ISCPMS 2018
CountryIndonesia
CityDepok
Period30/10/1831/10/18

Keywords

  • Curcuma longa
  • curcumin
  • curcumin isoxazole
  • isolation

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  • Cite this

    Nurjanah, N., & Saepudin, E. (2019). Curcumin isolation, synthesis and characterization of curcumin isoxazole derivative compound. In T. Mart, D. Triyono, & I. T. Anggraningrum (Eds.), Proceedings of the 4th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2018 [020065] (AIP Conference Proceedings; Vol. 2168). American Institute of Physics Inc.. https://doi.org/10.1063/1.5132492