Curcumin as Adjuvant Therapy in COVID-19: Friend or Foe?

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

COVID-19, which is caused by SARS-CoV-2, quickly spreads in many countries and was declared as a pandemic. To date, there is no effective drug that is proven against COVID-19. Curcumin has various beneficial effects, including anti-inflammatory, antioxidant, antimicrobial, and antiviral properties. Curcumin containing herbal drink is famous to boost immune response, and curcumin was shown to bind to viral S1 protein, which is important for viral entry, in an in silico study. Therefore, administration of curcumin containing herbal drink may be beneficial to prevent COVID-19 and cytokine storm in severe form of COVID-19. However, high dose curcumin was showed to increase expression of ACE2 in myocardial fibrosis rat model. Therefore, there is a fear that curcumin may help viral entry into the cell, as ACE2 is the receptor for SARS-CoV-2 entry into cells. However, looking at the dose of curcumin in the herbal drink, it is unlikely that the dose will cause an increase in ACE2. In conclusion, curcumin may be beneficial as adjuvant to other drugs to prevent COVID-19 and cytokine storm in severe COVID-19, but studies are needed to get more robust prove, and to determine the optimal dose and timing of administration.Review (J Int Dent Med Res 2020; 13(2): 824-829)

Original languageEnglish
Pages (from-to)824-829
Number of pages6
JournalJournal of International Dental and Medical Research
Volume13
Issue number2
Publication statusPublished - 29 Jun 2020

Keywords

  • ACE2
  • anti-inflamatory
  • COVID-19
  • Curcumin
  • cytokine storm
  • SARS-CoV-2

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