CSF1 gene associated with aggressive periodontitis in the Japanese population

D. Rabello, Nurtami, H. Kamei, Y. Ishihara, T. Noguchi, D. Fuma, M. Suzuki, Y. Sakaki, A. Yamaguchi, T. Kojima

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8 Citations (Scopus)


Aggressive periodontitis (AgP) is characterized by the early onset of the rapid and progressive destruction of the alveolar bone. We investigated the correlation of single nucleotide polymorphisms (SNPs) in candidate genes with AgP in the Japanese population in order to determine the genetic risk factors for this complex disease. Among 11 genes related to bone formation and resorption, 43 known SNPs were tested in 98 case and 88 control samples for association with AgP by using SNP genotyping techniques. Among these, three polymorphisms located in the colony stimulating factor 1 (CSF1) gene showed a positive association with AgP. This is the first case of an association between a CSF1 polymorphism and a human disease.

Original languageEnglish
Pages (from-to)791-796
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number3
Publication statusPublished - 1 Sep 2006


  • Aggressive periodontitis
  • CSF1 gene
  • Genetic polymorphism
  • Risk factor
  • Single nucleotide polymorphism (SNP)

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