Cryptosporidium species from human immunodeficiency-infected patients with chronic diarrhea in Jakarta, Indonesia

Agnes Kurniawan, Sri W. Dwintasari, Lisa Connelly, Rosely A.B. Nichols, Evy Yunihastuti, Teguh Haryono Karyadi, Samsuridjal Djauzi

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Purpose: Cryptosporidium is an opportunistic parasite that manifests as chronic and severe diarrhea in the immune-compromised subject. We investigated the species of Cryptosporidium to understand the epidemiology, mode of transmission, response to treatment, and prevention. Methods: Polymerase chain reaction/restriction fragment length polymorphism of the 18S rRNA gene and sequencing were performed on 41 Cryptosporidium-positive stools from 36 patients with HIV AIDS, which comprised 36 pretreatment stools and 5 stools after treatment with Paromomycin. Results: C. hominis, C. meleagridis, C. felis, and C. parvum were detected; 28 of 36 (77.7%) patients were infected with C. hominis and two (5.5%) patients with multiple species of Cryptosporidium. Treatment with Paromomycin resulted in different outcomes, perhaps because patients harbored other intestinal parasitic infections. Conclusions: Multiple infection with various Cryptosporidium species in the presence of other intestinal parasites occurs in patients with HIV AIDS suffering from chronic diarrhea who are severely immune-compromised. Common transmission of Cryptosporidium is anthroponotic.

Original languageEnglish
Pages (from-to)720-723
Number of pages4
JournalAnnals of Epidemiology
Volume23
Issue number11
DOIs
Publication statusPublished - 1 Nov 2013

Keywords

  • Cryptosporidium sp.
  • HIV AIDS
  • Multiple species
  • Transmission

Fingerprint Dive into the research topics of 'Cryptosporidium species from human immunodeficiency-infected patients with chronic diarrhea in Jakarta, Indonesia'. Together they form a unique fingerprint.

  • Cite this