TY - JOUR
T1 - Could combination of radical hysterectomy and radiation effective in the treatment of primary cervical signet ring cell carcinoma?
T2 - A rare case report
AU - Purwoto, Gatot
AU - Nuryanto, Kartiwa Hadi
AU - Wibowo, Taufik Agung
AU - Hellyanti, Tantri
AU - Syaharutsa, Danny Maesadatu
AU - Julianti, Kelli
N1 - Publisher Copyright:
© 2022 The Authors
PY - 2022/5
Y1 - 2022/5
N2 - Introduction: Primary signet-ring cell carcinoma (PSRCC) of the uterine cervix mostly occurs due to the metastasis from the primary organ, such as the gastrointestinal tract or breast. This case describes the cervical PSRCC and its management as a rare case. Presentation of case: The 39-year-old female came to undergo cancer screening. Visual Inspection with Acetic Acid (VIA) examination result was negative with the feature of severe cervicitis, and then the patient was given Trichloroacetic Acid (TCA) procedure. Three weeks after TCA's procedure, speculum examination found morphological features of cervix malignancy. Cervical biopsy examination showed mucinous adenocarcinoma, signet ring cell variant, with lymphovascular invasion. Endometrial microcurettage specimen do not contain tumor mass. Discussion: The risk factor for cervical cancer in this patient was early sexual intercourse. We suggested stage IB2 cervical cancer because the tumor size was 2 cm until 4 cm, there was no spreading to nearby lymph nodes nor distant sites. Then patient had performed a radical hysterectomy procedure with ovary transposition and a series of radiation therapy. The patient was in good condition and no metastases were found in the imaging study. Conclusion: The treatment of PSRCC of the uterine cervix is challenging. It was established from intraoperative findings, histopathology, and immunohistochemistry examination. The radical hysterectomy adjunct to radiation was effective in the treatment of the PSRCC of the uterine cervix.
AB - Introduction: Primary signet-ring cell carcinoma (PSRCC) of the uterine cervix mostly occurs due to the metastasis from the primary organ, such as the gastrointestinal tract or breast. This case describes the cervical PSRCC and its management as a rare case. Presentation of case: The 39-year-old female came to undergo cancer screening. Visual Inspection with Acetic Acid (VIA) examination result was negative with the feature of severe cervicitis, and then the patient was given Trichloroacetic Acid (TCA) procedure. Three weeks after TCA's procedure, speculum examination found morphological features of cervix malignancy. Cervical biopsy examination showed mucinous adenocarcinoma, signet ring cell variant, with lymphovascular invasion. Endometrial microcurettage specimen do not contain tumor mass. Discussion: The risk factor for cervical cancer in this patient was early sexual intercourse. We suggested stage IB2 cervical cancer because the tumor size was 2 cm until 4 cm, there was no spreading to nearby lymph nodes nor distant sites. Then patient had performed a radical hysterectomy procedure with ovary transposition and a series of radiation therapy. The patient was in good condition and no metastases were found in the imaging study. Conclusion: The treatment of PSRCC of the uterine cervix is challenging. It was established from intraoperative findings, histopathology, and immunohistochemistry examination. The radical hysterectomy adjunct to radiation was effective in the treatment of the PSRCC of the uterine cervix.
KW - Cervical carcinoma
KW - Radiation
KW - Radical hysterectomy
KW - Signet-ring cell
UR - http://www.scopus.com/inward/record.url?scp=85128180656&partnerID=8YFLogxK
U2 - 10.1016/j.ijscr.2022.107083
DO - 10.1016/j.ijscr.2022.107083
M3 - Article
AN - SCOPUS:85128180656
SN - 2210-2612
VL - 94
JO - International Journal of Surgery Case Reports
JF - International Journal of Surgery Case Reports
M1 - 107083
ER -