Cost-effectiveness analysis on measles transmission with vaccination and treatment intervention

Shinta A. Rahmayani, Dipo Aldila, Bevina D. Handari

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


A deterministic model which describes measles’ dynamic using newborns and adults first and second dose of vaccination and medical treatment is constructed in this paper. Mathematical analysis about existence of equilibrium points, basic reproduction number, and bifurcation analysis conducted to understand qualitative behaviour of the model. For numerical purposes, we estimated the parameters’ values of the model using monthly measles data from Jakarta, Indonesia. Optimal control theory was applied to investigate the optimal strategy in handling measles spread. The results show that all controls succeeded in reducing the number of infected individuals. The cost-effective analysis was conducted to determine the best strategy to reduce number of infected individuals with the lowest cost of intervention. Our result indicates that the use of the first dose measles vaccine with medical treatment is the most optimal strategy to control measles transmission.

Original languageEnglish
Pages (from-to)12491-12527
Number of pages37
JournalAIMS Mathematics
Issue number11
Publication statusPublished - 2021


  • Basic reproduction number
  • Cost-effective analysis
  • Forward bifurcation
  • Measles
  • Optimal control


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