Correlation of toluene safe duration (Hours/day) and glutathione concentration, malondialdehyde and neurotoxic symptoms in Osowilangun shoe home industry workers

Diah Pramesthi Ningrum, Abdul Rohim Tualeka, Juliana Jalaludin, Syamsiar S. Russeng, Pudji Rahmawati, Ahsan Ahsan, Indri H. Susilowati

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Exposure of toluene can cause a decrease in glutathione concentration, increase in malondialdehyde and neurotoxic symptoms. The safe duration of toluene in hours/day for each person can vary. The purpose of this study is to determine the relationship between the safe duration of toluene (hours/ day) with the concentration of glutathione, malondialdehyde and neurotoxic symptoms in Osowilangun shoe home industry workers. Methods: This research was observational with quantitative approach and cross-sectional design. The sampling technique used was accidental sampling with 25 respondents. The variables studied were safe toluene duration (hours/day), glutathione concentration, malondialdehyde concentration, and neurotoxic symptoms. Data were analyzed using Pearson and Phi correlation. Result: The average of safe duration was 1,489 hours/day, glutathione concentration was 58,349 µg/L, and malondialdehyde was 7,847 MU. As many as 11 out of 14 workers experienced neurotoxic symptoms. The relationship between safe duration (hours/day) with glutathione concentration (r=0.139) and malondialdehyde (r=-0.146) was very weak. While, the relationship between safe duration (hours/day) and neurotoxic symptoms was weak (φ=-0.223). Conclusion: The relationship between safe duration in hours/day with glutathione concentration and malondialdehyde was very weak, while relationship with neurotoxic symptoms was weak.

Original languageEnglish
Pages (from-to)868-874
Number of pages7
JournalIndian Journal of Forensic Medicine and Toxicology
Volume14
Issue number4
DOIs
Publication statusPublished - 1 Oct 2020

Keywords

  • Glutathione
  • Malondialdehyde
  • Neurotoxic symptoms
  • Safe concentration
  • Toluene

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