Correlation of (PRO)renin receptor and vascular endothelial growth factor expression level in third trimester of preeclampsia placentas

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Abstract

Objective: This cross-sectional study was designed to correlate the expression of mRNA and protein of (pro)renin receptor ([P]RR) and vascular endothelial growth factor (VEGF) gene in preeclampsia placentas. Methods: We used 34 placenta tissues of normal pregnancy and 34 preeclampsia placenta tissues. Real-time polymerase chain reaction was used to measure relative expression of VEGF and (P)RR mRNAs, and protein concentration was measured using Sandwich ELISA technique. Results: VEGF mRNA relative expression of preeclampsia placenta was 2.83 times higher than the normal placenta (p=0.02). (P)RR mRNA relative expression on preeclampsia placenta was 1.7 times higher than the normal one (p=0.039). Expression of protein (P)RR and VEGF was lower on preeclampsia shown by p<0.05, R=0.441. From this research, it was considered that low protein of (P)RR and VEGF contributes to preeclampsia. Conclusion: There was a correlation between (P)RR and VEGF. It considers that there is any involvement of (P)RR on angiogenesis through VEGF expression in preeclampsia placenta.

Original languageEnglish
Pages (from-to)308-312
Number of pages5
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume11
Issue number12
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • (Pro) renin receptor/(P)RR
  • Placenta
  • Preeclampsia
  • Vascular endothelial growth factor

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