Correlation of Ki-67 with Radiation Response and Grade in Meningiomas: A Systematic Review

Fenny Tjuatja; Handoko; Henry Kodrat; Reyhan E. Yunus; Eka Susanto; Tiara Anindhita; Renindra A. Aman; Soehartati Gondhowiardjo; Sri M. Sekarutami

Correlation of Ki-67 with Radiation Response and Grade in Meningiomas: A Systematic Review

Fenny Tjuatja, Handoko, Henry Kodrat, Reyhan E. Yunus, Eka Susanto, Tiara Anindhita, Renindra A. Aman, Soehartati Gondhowiardjo, Sri M. Sekarutami

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1 Citation (Scopus)

Abstract

PURPOSE: This systematic review aimed to identify the role of Ki-67 as a prognostic factor in estimating tumor grade and the radiation response in meningiomas. METHODS: A systematic search of the literature on meningiomas was carried out through the PubMed, Scopus, and EBSCOhost databases according to the PRISMA guidelines. RESULTS: Our search resulted in 465 collected articles, 15 of which satisfied the eligibility criteria. Twelve studies reported the correlation between Ki-67 and meningioma grade. Two other investigations reported the relationship between Ki-67 and the radiation response in meningioma, and one failed to capture the association between Ki-67 and the radiation response in meningioma. CONCLUSION: The Ki-67 proliferation index has a uniform correlation with meningioma grade. Two of the 3 studies on the correlation of Ki-67 with the radiation response in meningioma patients reported that patients with a higher Ki-67 responded better to radiation therapy.

Original language	English
Pages (from-to)	58-66
Number of pages	9
Journal	The gulf journal of oncology
Volume	1
Issue number	40
Publication status	Published - 1 Sept 2022

Keywords

Ki-67
Meningioma grade
Radiation therapy response Systematic review.

Cite this

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title = "Correlation of Ki-67 with Radiation Response and Grade in Meningiomas: A Systematic Review",

abstract = "PURPOSE: This systematic review aimed to identify the role of Ki-67 as a prognostic factor in estimating tumor grade and the radiation response in meningiomas. METHODS: A systematic search of the literature on meningiomas was carried out through the PubMed, Scopus, and EBSCOhost databases according to the PRISMA guidelines. RESULTS: Our search resulted in 465 collected articles, 15 of which satisfied the eligibility criteria. Twelve studies reported the correlation between Ki-67 and meningioma grade. Two other investigations reported the relationship between Ki-67 and the radiation response in meningioma, and one failed to capture the association between Ki-67 and the radiation response in meningioma. CONCLUSION: The Ki-67 proliferation index has a uniform correlation with meningioma grade. Two of the 3 studies on the correlation of Ki-67 with the radiation response in meningioma patients reported that patients with a higher Ki-67 responded better to radiation therapy.",

keywords = "Ki-67, Meningioma grade, Radiation therapy response Systematic review.",

author = "Fenny Tjuatja and Handoko and Henry Kodrat and Yunus, {Reyhan E.} and Eka Susanto and Tiara Anindhita and Aman, {Renindra A.} and Soehartati Gondhowiardjo and Sekarutami, {Sri M.}",

year = "2022",

month = sep,

day = "1",

language = "English",

volume = "1",

pages = "58--66",

journal = "The gulf journal of oncology",

issn = "2078-2101",

publisher = "Gulf Federation for Cancer Control",

number = "40",

}

TY - JOUR

T1 - Correlation of Ki-67 with Radiation Response and Grade in Meningiomas

T2 - A Systematic Review

AU - Tjuatja, Fenny

AU - Handoko,

AU - Kodrat, Henry

AU - Yunus, Reyhan E.

AU - Susanto, Eka

AU - Anindhita, Tiara

AU - Aman, Renindra A.

AU - Gondhowiardjo, Soehartati

AU - Sekarutami, Sri M.

PY - 2022/9/1

Y1 - 2022/9/1

N2 - PURPOSE: This systematic review aimed to identify the role of Ki-67 as a prognostic factor in estimating tumor grade and the radiation response in meningiomas. METHODS: A systematic search of the literature on meningiomas was carried out through the PubMed, Scopus, and EBSCOhost databases according to the PRISMA guidelines. RESULTS: Our search resulted in 465 collected articles, 15 of which satisfied the eligibility criteria. Twelve studies reported the correlation between Ki-67 and meningioma grade. Two other investigations reported the relationship between Ki-67 and the radiation response in meningioma, and one failed to capture the association between Ki-67 and the radiation response in meningioma. CONCLUSION: The Ki-67 proliferation index has a uniform correlation with meningioma grade. Two of the 3 studies on the correlation of Ki-67 with the radiation response in meningioma patients reported that patients with a higher Ki-67 responded better to radiation therapy.

AB - PURPOSE: This systematic review aimed to identify the role of Ki-67 as a prognostic factor in estimating tumor grade and the radiation response in meningiomas. METHODS: A systematic search of the literature on meningiomas was carried out through the PubMed, Scopus, and EBSCOhost databases according to the PRISMA guidelines. RESULTS: Our search resulted in 465 collected articles, 15 of which satisfied the eligibility criteria. Twelve studies reported the correlation between Ki-67 and meningioma grade. Two other investigations reported the relationship between Ki-67 and the radiation response in meningioma, and one failed to capture the association between Ki-67 and the radiation response in meningioma. CONCLUSION: The Ki-67 proliferation index has a uniform correlation with meningioma grade. Two of the 3 studies on the correlation of Ki-67 with the radiation response in meningioma patients reported that patients with a higher Ki-67 responded better to radiation therapy.

KW - Ki-67

KW - Meningioma grade

KW - Radiation therapy response Systematic review.

UR - http://www.scopus.com/inward/record.url?scp=85143081950&partnerID=8YFLogxK

M3 - Article

C2 - 36448071

AN - SCOPUS:85143081950

SN - 2078-2101

VL - 1

SP - 58

EP - 66

JO - The gulf journal of oncology

JF - The gulf journal of oncology

IS - 40

ER -

Correlation of Ki-67 with Radiation Response and Grade in Meningiomas: A Systematic Review

Abstract

Keywords

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