Cervical cancer is the second commonest cancer in Indonesia, with 2,638 cases reported in 2008. Most therapeutic recommendations currently address squamous cell carcinomas, and some studies suggest that adenocarcinomas exhibit poor response to treatment. This study aimed to examine the correlation between the histopathological types of cervical cancer and response to therapy and to compare the responses to different treatment modalities. This cross-sectional study included secondary data of patients diagnosed with stage IIB-IIIB cervical cancer between 2011-2013 at Cipto Mangunkusumo Hospital who underwent radiation and chemoradiation. Of the 163 patients included in this study, 107 presented with squamous cell carcinoma and 56 with adenocarcinoma. No significant differences in response to therapy were observed between the two histopathological types. Moreover, 67.5% patients received radiation only, whereas 32.5% received concurrent chemoradiation therapy using a platinum-based agent. Among those treated with chemoradiation, 98.1% exhibited complete response, whereas only 72.7% of those receiving radiation exhibited complete response. Irrespective of the treatment type, no differences in the response to therapy were observed between patients with squamous cell carcinoma and adenocarcinoma. Moreover, chemoradiation appeared to induce a better response compared with only radiation in all patients.
|Journal of Physics: Conference Series
|Published - 7 Sept 2018
|2nd Physics and Technologies in Medicine and Dentistry Symposium, PTMDS 2018 - Depok, West Java, Indonesia
Duration: 18 Jul 2018 → 18 Jul 2018