We have investigated the relationship between prostate volume, prostate specific antigen (PSA), prostate specific antigen density (PSAD) and age in 873 patients with benign prostatic hyperplasia. The mean age was 65 ± 8.8 years, the mean prostate volumes were 50 ± 24,6 ml, which is bigger compared to the data from western countries and also in Japan and Taiwan. The mean PSA level was 12.9 ± 18,2 ng/ml and the mean PSAD in this study was 0.25 ± 0,31. There was a modest correlation between prostate volume - age, PSA - age and PSAD - age, Spearman correlation coefficients were r=0.182, p<0.01, r=0.264, p<0.0l, r=0.232, p<0.01 respectively and there was a strong correlation between PSA and prostate volume (Spearman correlation coefficient r= 0.502, p<0.01).In conclusion, serum PSA level is strongly related to prostate volume in men with BPH with no evidence of prostate cancer. Since the PSA level and the PSAD in this study was higher than the other country with high incidence of prostate cancer, we need futher study to determine our own cut off level of PSA and PSAD in Indonesian benign prostate hyperplasia patiens.
- Prostate volume