Correlation between LDL, HDL, Total Cholesterol, and Triglyceride with the Degree of Chronic Kidney Disease in Children

Chronic kidney disease (CKD) is a noncommunicable harmful disease that might decrease child quality of life. The mortality is mostly caused by cardiovascular disease and dyslipidemia as the major risk factor. At present there is lack of study about the correlation between lipid profile and degree of CKD in children. Underlying causes in adults and children are quite different, so it is very important to find out the lipid profile in various degrees of CKD in children. This cross-sectional study was carried out during January - June 2016 in Hasan Sadikin Hospital Bandung and M Djamil General Hospital Padang, Indonesia. Samples were collected consecutively, calculated from coefficient determinant. The power samples gained with G*Power software were 41 children. The study was permitted by the Ethical Committee Hasan Sadikin and M Djamil General Hospital. The correlation was analyzed using multiple linear regression with SPSS 24.0. From the samples we performed ureum, creatinine, LDL, HDL, triglyceride, and total cholesterol. The degree of CKD based on glomerular filtration rate (GFR) was determined by Schwartz formula. The sample consisted of 87 children with CKD stage 1 - 5 respectively (43, 11, 8, 8, 17). Correlation between GFR with LDL, HDL, triglyceride, and total cholsterol level were: rs=0.29, IK 95% (0.08; 0.49), p=0.007; rs=0.16, IK 95% (-0.07; 0.37), p=0.150; rs=-0.05, IK 95% (-0.26; 0.15), p=0.625; and rs=0.25; IK 95% (0.04; 0.45), p=0.022, respectively. There were significant correlation between various degrees of CKD with LDL and total cholesterol. No significant correlation between various degree of CKD with HDL and triglyceride.