Correlation between hba1c level and lipid profile in prediabetes individuals

Introduction: According to previous research, it was found that hyperglycemic conditions caused by insulin resistance in Diabetes mellitus patients are associated with abnormalities in lipid profile. Since the correlation of such conditions in prediabetes individuals was not much explored, this research aims to investigate the correlation between HbA1c level and lipid profile in prediabetes individuals. Methods: This research is a crosssectional study using secondary data from Dr. Cipto Mangunkusumo hospital laboratory. Samples were 69 patients with prediabetes according to their HbA1c level between 5,7%–6,4% in the period of January 2015 until December 2015. The data were analyzed by using the Spearman’s correlation test to determine the correlation. Results: There is a significant correlation between HbA1c level and triglyceride, as well as HbA1c level and total cholesterol. Correlation between HbA1c level and tryglyceride showed a weak negative correlation (p: 0,045; r : −0,242). Correlation between HbA1c level and total cholesterol showed a weak negative correlation (p: 0,027; r : −0,266). Conclusion: In conclusion, there is a weak negative correlation between HbA1c level and lipid profile (triglyceride and total cholesterol) in prediabetes individuals. Such conditions might occur due to the absence of insulin resistance or the presence of the other factors that further contribute to the abnormalities in lipid profile compared to HbA1c level.