Continuous environmental enrichment and aerobic exercise improves spatial memory: Focus on rat hippocampal BDNF and NGF

Research output: Contribution to journalArticlepeer-review

Abstract

Memory is an important cognitive function in humans. Exercise and environmental enrichment (EE) exposure have positive effects on memory function via improved neurogenesis through expression of growth factors such as brainderived neurotrophic factor (BDNF) and nerve growth factor (NGF). Exercise and environmental enrichment have independently been shown to increase BDNF and NGF, but the effect of the combination of these treatments has not been widely studied. This experimental study aims to analyse the effect of aerobic exercise, EE exposure, and combination of aerobic exercise and EE exposure on memory function. This study used twenty 7-month old male Wistar rats that were given treatment for 8 weeks. Memory function was tested using forced alternation Y-maze. Hippocampal expression of BDNF and NGF were also assessed. The results showed the combination group has highest performance in memory function test and also the highest level of hippocampal BDNF and NGF (P<0.05). It can be concluded that the combination of aerobic exercise and continuous EE exposure produces the best results for memory function through higher levels of hippocampal BDNF and NGF in adult rats.

Original languageEnglish
Pages (from-to)121-128
Number of pages8
JournalComparative Exercise Physiology
Volume16
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • Aerobic exercise
  • BDNF
  • Environmental enrichment
  • NGF
  • Spatial memory

Fingerprint Dive into the research topics of 'Continuous environmental enrichment and aerobic exercise improves spatial memory: Focus on rat hippocampal BDNF and NGF'. Together they form a unique fingerprint.

Cite this