Contamination analysis of antimicrobial resistance in escherichia coli in the domestic environment

Antimicrobial resistance (AMR) is one of the top 10 global public health. In Indonesia, little is known about the prevalence of Extended-Spectrum Beta-Lactamase (ESBL)-producing E. coli in the environment increases the risk of contamination of groundwater sources because of the potential for rapid colonization through the water. A study validation in AMR E. coli was carried out in the rainy season (March 2020). The results showed that 33.3% (20/60) of groundwater samples were positive for resistance to the antibiotic cefotaxime. This research aimed to determine the significance of seasonal variations in contamination of AMR and the correlation AMR present with faecal sources. The results showed that 22.2% (12/54) of groundwater samples were positive for cefotaxime antibiotic resistance with comparison test on seasonal variations shows a significant difference in E. coli contamination (p = 0.045), but not in AMR E. coli contamination (p = 0.234). The correlation relationship of the contamination from faecal sources on AMR E. coli in water sources shows a significant correlation (p-value 0.041) because of the use of on-site sanitation but no correlation between livestock ownership (p-value 0.891).