Contact allergy due to colophony (VII), Sensitizing studies with oxidation products of abietic and related acids

B. M. Hausen, K. Krohn, Emil Budianto

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40 Citations (Scopus)

Abstract

9 oxidation products of abietic acid, dehydroabietic acid, and levopimaric acid were prepared synthetically to determine their sensitizing potential in guinea pigs. It was found that compounds with epoxy and peroxo groups in rings A and B had a notable sensitizing potential. The same result was found with 7‐oxode‐hydroabietic acid identified earlier in rosin (3) and a polar fraction obtained from commercial abietic acid, suggesting the presence of still unidentified oxidation products. Hydroxylation of rings A or B, or conversion to the methyl esters, considerably decreases the sensitizing potential. A model is presented underlining the importance of hydrophobic and polar domains addition to chemically reactive groupings, in the allergen. Insertion into the lipid bilayer may play an important rôle in contact sensitivity.

Original languageEnglish
Pages (from-to)352-358
Number of pages7
JournalContact Dermatitis
Volume23
Issue number5
DOIs
Publication statusPublished - 1 Jan 1990

Keywords

  • chemical basis
  • colophony
  • contact allergy
  • guinea pig sensitization
  • oxo, hydroxy, epoxy, and peroxido derivatives of abietic acid

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