Contact allergy due to colophony: (IX). Sensitization studies with further products isolated after oxidative degradation of resin acids and colophony

B. M. Hausen, M. Böurries, Emil Budianto, K. Krohn

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Degradation of abietic, levopimaric and dehydroabietic acids after exposure to air and light over a period of one to several months, as well its examination of degraded French tall oil rosin and Portuguese colophony, led to the isolation of numerous oxidation products. These compounds were synthesized and consigned to experimental sensitization in guinea pigs. From 20 substances studied as acids or as their methyl esters, in the present and preceding paper, at least 2 can be named: 8.12‐peroxydo‐δ13(14)‐dihydroabietic acid and 12 α‐hydroxyabietic acid, that contribute a great deal to colophony allergy by both their sensitizing capacity and their determined concentration in the mixture of degradation products. We recommend the preparation of a new mixture oxidation products for patch testing in the diagnosis of contact allergy to colophony.

Original languageEnglish
Pages (from-to)234-240
Number of pages7
JournalContact Dermatitis
Volume29
Issue number5
DOIs
Publication statusPublished - 1 Jan 1993

Keywords

  • colophony
  • contact allergy
  • guinea pig sensitization
  • modified‐colophony products
  • oxo, hydroxyl, peroxy derivatives of resin acids
  • patch testing technique
  • synthesis of oxidation products

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