Computation Validation of EF Distribution Measured by Wire Mesh Tomography (WMT) for Electro-Capacitive Cancer Therapy (ECCT) Optimization

Muhammad Arif, Warsito Purwo Taruno, Septelia Inawati Wanandi, Anto Sulaksono

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Previous studies showed that the intensity of electric fields (EF) preferentially inhibits cancer cell division during mitosis at intermediate frequencies. Cancer cells have different physiological activities from normal cells, resulting in different electrical activities between the cancer cells and the surrounding normal tissue. Many researchers have researched the effects of EF intensity distribution on cancer cell division utilizing EF intensity distribution measurement. However, variations in cancer cells' surrounding tissue and cancer cells are due to electric properties property differences that have not been studied well. The acting force varies with different media surrounding tumor mass and affects treatment effectiveness. To verify the EF's role in the cancer cell division, we developed a wired mesh tomography (WMT) sensor to measure EF intensity distributions inside and around the tumor phantom with different surrounding media. The WMT sensor consists of a 10 x 10 wire matrix in a rectangular block vessel 10 cm x 12 cm in width and length. A simulation using a tumor phantom in the shape of a tube is carried out to compare the EF distributions measured using the WMT to validate the measurement technique. The measurement and simulation are conducted on nodules surrounded by medium, namely air, and silicone. The EF distributions obtained by measurement and computation optimize the treatment planning system using ECCT (Electro-Capacitive Cancer Treatment). Using WMT methods, the EF intensity resulting from measurement and simulation on a nodule surrounded by medium shows have a similar trend. The simulation data confirms that the dielectric properties of a nodule and medium affect the EF intensity on the material and its gradient when the EF is on the boundary.

Original languageEnglish
Title of host publication6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the 6th International Symposium of Biomedical Engineering, ISBE 2021
EditorsSiti Fauziyah Rahman, Ahmad Zakiyuddin, Yudan Whulanza, Nurul Intan
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735443716
DOIs
Publication statusPublished - 16 Aug 2022
Event6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021 - Depok, Virtual, Indonesia
Duration: 7 Jul 20218 Jul 2021

Publication series

NameAIP Conference Proceedings
Volume2537
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021
Country/TerritoryIndonesia
CityDepok, Virtual
Period7/07/218/07/21

Keywords

  • ECCT
  • EF
  • the dielectric constant
  • validation
  • wire mesh sensor

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