TY - GEN
T1 - Computation Validation of EF Distribution Measured by Wire Mesh Tomography (WMT) for Electro-Capacitive Cancer Therapy (ECCT) Optimization
AU - Arif, Muhammad
AU - Taruno, Warsito Purwo
AU - Wanandi, Septelia Inawati
AU - Sulaksono, Anto
N1 - Publisher Copyright:
© 2022 American Institute of Physics Inc.. All rights reserved.
PY - 2022/8/16
Y1 - 2022/8/16
N2 - Previous studies showed that the intensity of electric fields (EF) preferentially inhibits cancer cell division during mitosis at intermediate frequencies. Cancer cells have different physiological activities from normal cells, resulting in different electrical activities between the cancer cells and the surrounding normal tissue. Many researchers have researched the effects of EF intensity distribution on cancer cell division utilizing EF intensity distribution measurement. However, variations in cancer cells' surrounding tissue and cancer cells are due to electric properties property differences that have not been studied well. The acting force varies with different media surrounding tumor mass and affects treatment effectiveness. To verify the EF's role in the cancer cell division, we developed a wired mesh tomography (WMT) sensor to measure EF intensity distributions inside and around the tumor phantom with different surrounding media. The WMT sensor consists of a 10 x 10 wire matrix in a rectangular block vessel 10 cm x 12 cm in width and length. A simulation using a tumor phantom in the shape of a tube is carried out to compare the EF distributions measured using the WMT to validate the measurement technique. The measurement and simulation are conducted on nodules surrounded by medium, namely air, and silicone. The EF distributions obtained by measurement and computation optimize the treatment planning system using ECCT (Electro-Capacitive Cancer Treatment). Using WMT methods, the EF intensity resulting from measurement and simulation on a nodule surrounded by medium shows have a similar trend. The simulation data confirms that the dielectric properties of a nodule and medium affect the EF intensity on the material and its gradient when the EF is on the boundary.
AB - Previous studies showed that the intensity of electric fields (EF) preferentially inhibits cancer cell division during mitosis at intermediate frequencies. Cancer cells have different physiological activities from normal cells, resulting in different electrical activities between the cancer cells and the surrounding normal tissue. Many researchers have researched the effects of EF intensity distribution on cancer cell division utilizing EF intensity distribution measurement. However, variations in cancer cells' surrounding tissue and cancer cells are due to electric properties property differences that have not been studied well. The acting force varies with different media surrounding tumor mass and affects treatment effectiveness. To verify the EF's role in the cancer cell division, we developed a wired mesh tomography (WMT) sensor to measure EF intensity distributions inside and around the tumor phantom with different surrounding media. The WMT sensor consists of a 10 x 10 wire matrix in a rectangular block vessel 10 cm x 12 cm in width and length. A simulation using a tumor phantom in the shape of a tube is carried out to compare the EF distributions measured using the WMT to validate the measurement technique. The measurement and simulation are conducted on nodules surrounded by medium, namely air, and silicone. The EF distributions obtained by measurement and computation optimize the treatment planning system using ECCT (Electro-Capacitive Cancer Treatment). Using WMT methods, the EF intensity resulting from measurement and simulation on a nodule surrounded by medium shows have a similar trend. The simulation data confirms that the dielectric properties of a nodule and medium affect the EF intensity on the material and its gradient when the EF is on the boundary.
KW - ECCT
KW - EF
KW - the dielectric constant
KW - validation
KW - wire mesh sensor
UR - http://www.scopus.com/inward/record.url?scp=85138249232&partnerID=8YFLogxK
U2 - 10.1063/5.0101320
DO - 10.1063/5.0101320
M3 - Conference contribution
AN - SCOPUS:85138249232
T3 - AIP Conference Proceedings
BT - 6th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Rahman, Siti Fauziyah
A2 - Zakiyuddin, Ahmad
A2 - Whulanza, Yudan
A2 - Intan, Nurul
PB - American Institute of Physics Inc.
T2 - 6th International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2021
Y2 - 7 July 2021 through 8 July 2021
ER -
