Complete hematological response with imatinib mesylate in a corticosteroid refractory idiopathic hypereosinophilic syndrome in person living with HIV: A case report

Anna Mira Lubis; Evy Yunihastuti; Agnes Stephanie Harahap; Gabriella Anindyah; Amirah Yasmin; Matdoan Rifkiah Aisyah

doi:10.1177/09564624251338593

Complete hematological response with imatinib mesylate in a corticosteroid refractory idiopathic hypereosinophilic syndrome in person living with HIV: A case report

Anna Mira Lubis
, Evy Yunihastuti
, Agnes Stephanie Harahap
, Gabriella Anindyah
, Amirah Yasmin
, Matdoan Rifkiah Aisyah

Research output: Contribution to journal › Article › peer-review

Abstract

We present a case of a 38-year-old person living with HIV (PLHIV) diagnosed with refractory idiopathic hypereosinophilic syndrome (HES). His initial symptoms were pruritic skin rash, dry cough, and diarrhea. The patient was unresponsive to corticosteroid as a first-line therapy. Subsequent treatment with Imatinib mesylate 100 mg per day resulted in excellent and sustained hematological and clinical response, with a likely molecular response as well.

Original language	English
Article number	09564624251338593
Journal	International Journal of STD and AIDS
DOIs	https://doi.org/10.1177/09564624251338593
Publication status	Accepted/In press - 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

FIP1L1-PDGFRA mutation
Human immunodeficiency virus (HIV)
hypereosinophilic syndrome (HES)
imatinib

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10.1177/09564624251338593

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Lubis, A. M., Yunihastuti, E., Harahap, A. S., Anindyah, G., Yasmin, A., & Aisyah, M. R. (Accepted/In press). Complete hematological response with imatinib mesylate in a corticosteroid refractory idiopathic hypereosinophilic syndrome in person living with HIV: A case report. International Journal of STD and AIDS, Article 09564624251338593. https://doi.org/10.1177/09564624251338593

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title = "Complete hematological response with imatinib mesylate in a corticosteroid refractory idiopathic hypereosinophilic syndrome in person living with HIV: A case report",

abstract = "We present a case of a 38-year-old person living with HIV (PLHIV) diagnosed with refractory idiopathic hypereosinophilic syndrome (HES). His initial symptoms were pruritic skin rash, dry cough, and diarrhea. The patient was unresponsive to corticosteroid as a first-line therapy. Subsequent treatment with Imatinib mesylate 100 mg per day resulted in excellent and sustained hematological and clinical response, with a likely molecular response as well.",

keywords = "FIP1L1-PDGFRA mutation, Human immunodeficiency virus (HIV), hypereosinophilic syndrome (HES), imatinib",

author = "Lubis, \{Anna Mira\} and Evy Yunihastuti and Harahap, \{Agnes Stephanie\} and Gabriella Anindyah and Amirah Yasmin and Aisyah, \{Matdoan Rifkiah\}",

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doi = "10.1177/09564624251338593",

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T2 - A case report

AU - Lubis, Anna Mira

AU - Yunihastuti, Evy

AU - Harahap, Agnes Stephanie

AU - Anindyah, Gabriella

AU - Yasmin, Amirah

AU - Aisyah, Matdoan Rifkiah

PY - 2025

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N2 - We present a case of a 38-year-old person living with HIV (PLHIV) diagnosed with refractory idiopathic hypereosinophilic syndrome (HES). His initial symptoms were pruritic skin rash, dry cough, and diarrhea. The patient was unresponsive to corticosteroid as a first-line therapy. Subsequent treatment with Imatinib mesylate 100 mg per day resulted in excellent and sustained hematological and clinical response, with a likely molecular response as well.

AB - We present a case of a 38-year-old person living with HIV (PLHIV) diagnosed with refractory idiopathic hypereosinophilic syndrome (HES). His initial symptoms were pruritic skin rash, dry cough, and diarrhea. The patient was unresponsive to corticosteroid as a first-line therapy. Subsequent treatment with Imatinib mesylate 100 mg per day resulted in excellent and sustained hematological and clinical response, with a likely molecular response as well.

KW - FIP1L1-PDGFRA mutation

KW - Human immunodeficiency virus (HIV)

KW - hypereosinophilic syndrome (HES)

KW - imatinib

UR - https://www.scopus.com/pages/publications/105004467875

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DO - 10.1177/09564624251338593

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M1 - 09564624251338593

ER -

Complete hematological response with imatinib mesylate in a corticosteroid refractory idiopathic hypereosinophilic syndrome in person living with HIV: A case report

Abstract

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Keywords

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