Comparison of the effects of walking and bench-step exercise on osteocalcin and CTX-1 in post-menopausal women with osteopenia

Ignatio Rika Haryono, Angela Bibiana Maria Tulaar Y De Kort, Herawati Sudoyo, Ambrosius Purba, Murdani Abdullah, Sri Widia Jusman, Andri Maruli Tua Lubis, Ermita I. Ibrahim Ilyas

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1 Citation (Scopus)

Abstract

Purpose: Bench-step exercise produces biomechanical movements beneficial to improve bone remodeling. However, no studies have confirmed the effects of bench-step exercise (BE) on bone formation and resorption. The goal of this study is to compare the effects of bench-step and walking exercise (WE) on changes in osteocalcin and CTX-1 levels. Methods: Fifty-nine sedentary post-menopausal women with osteopenia (T-score between -1 and -2.5) were randomly divided into two groups: WE group (n=29) and BE group (n=30). Subjects performed 12 weeks of exercise. The osteocalcin and CTX-1 levels were analyzed using enzyme-linked immunosorbent assay. Independent t-test or Wilcoxon test was used to analyze the osteocalcin and CTX-1 levels. The difference in changes in the osteocalcin and CTX-1 between the groups before and after was analyzed using Mann-Whitney test. Results: The results showed a significant increase in the osteocalcin and CTX-1 levels in both groups (P<0.05). The increased levels of osteocalcin between groups were not statistically different (P>0.367). The increase in CTX-1 resulting from BE was lower than that from WE (P<0.048). Conclusion: This study indicates that BE may inhibit resorption stronger than WE.

Original languageEnglish
Article number1750012
JournalJournal of Musculoskeletal Research
Volume20
Issue number2
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • Bone formation
  • Bone resorption
  • Mechanical stimuli

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