Comparison of Telomerase Expression in Endometrioid Adenocarcinoma with Normal Endometrium

Objective: To examine and compare the expression of telomerase in endometrioid adenocarcinoma and normal endometrium using immunohistochemical staining. In the current study using immunohistochemical staining, telomerase expression were significantly different between endometrioid adenocarcinoma and normal endometrium.Method: Eleven samples of endometrioid cancer and ten samples of normal endometrium were obtained from hysterectomy specimens. All block paraffin samples underwent the immunohistochemical staining. Telomerase expression was scored semiquantitatively. Statistical analyses were performed using the Kolmogorov- Smirnov and Fisher test.Result: Telomerase expression in endometrioid adenocarcinoma was higher than in normal endometrium. Weak telomerase expression had 11.2 times (1.04-120.36; CI 95%; p = 0.037), and moderate telomerase expression was 35.0 times (1.74-703.0; CI95%; p = 0.016) higher relation to endometrioid cancer, compared with negative telomerase expression.Conclusion: Telomerase expression has a potential role to be used as a prediction tool whether a normal endometrium cell has a tendency to become endometrioid cancer.[Indones J Obstet Gynecol 2011; 35-4:230-4]Keywords: telomerase expression, endometrioid cancer