Comparison of Natural Salicylic Acid Level in Serum and Urine in Early-Onset and Late-Onset Preeclampsia, Case-control study

Objective: To determine the natural salicylic acid levels in normotension and preeclampsia who were not taking Acetylsalicylic Acid Design: A case-control study Setting: A university medical center Population: A case-control study of 148 pregnant women divided into four groups: normotension 20-34 weeks (n=35), normotension >34 - 40 weeks (n=39), early-onset preeclampsia (n=35), and late-onset preeclampsia (n=39). Method: The four groups were matched at a ratio of 1:1 concerning a gestational week. Socio-demographic characteristics and reproductive history were compared among the four groups. The numeric data were checked for normal distribution using the Kolmogorov Smirnov test, presented as mean ± SD if normally distributed and as median (IQR) if not normally distributed, Kruskal Wallis test was used to identify significances among groups and performed with Mann Whitney test. Result: Serum SUA level in EOP were significantly different from normotension with median 1.43 μmol/L (min-max 0.001-9.32) versus 0.21 μmol/L (0.002-15.78) (p<0.05), albumin in EOP significantly lower from normotension, median 3 gr/dl (2.1-3.8) vs 3.7 gr/dl (3.4-4.3) (p<0.05), and protein intake significantly lower than normotension (13% vs 14%, p<0,05) and correlates with SUA serum (r -0.572).There was no significant difference of SA and SUA in LOP and normotension, albumin level on LOP significantly lower with median 3 gr/dl vs 3.4 gr/dl(p<0.05). Conclusion: There was no significant difference in salicylic acid and salicyluric acid levels in serum and urine in preeclampsia and normotension. The serum SUA levels in the EOP group were greater and associated with low albumin levels and low protein intake.