Comparison of insulin-like growth factor-1 and sclerostin levels between premenopausal women with and without diabetes mellitus

Mahriani Sylvawani, Bambang Setyohadi, Dyah Purnamasari, Murdani Abdullah, Muhammed R. Kurniawan

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: This study assesses the serum levels of insulin-like growth factor-1 (IGF-1) and sclerostin as markers of decreased bone formation in premenopausal women with type 2 diabetes mellitus. Methods: A cross-sectional study was conducted to measure serum levels of IGF-1 and sclerostin in 40 premenopausal women with and without diabetes mellitus using an enzyme-linked immunosorbent assay. The levels of IGF-1 and sclerostin were compared between the groups using the Mann Whitney test and unpaired t-test, respectively. Results: The median IGF-1 serum levels were 40.60 ng/mL and 42.7 ng/mL in the diabetic and non-diabetic groups, respectively, with no significant difference. The serum levels of sclerostin were significantly higher in the diabetic group than in the non-diabetic group (132.1 pg/mL and 96.0 pg/mL, respectively; p < 0.001). Conclusion: The levels of sclerostin were significantly higher in premenopausal women with diabetes mellitus than in the non-diabetic group. Since sclerostin influences the differentiation and maturation of osteoblasts, serum sclerostin might potentially be useful as a marker of decreased bone formation in premenopausal women with diabetes.

Original languageEnglish
JournalJournal of Taibah University Medical Sciences
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Diabetes mellitus
  • IGF-1
  • Osteoblasts
  • Premenopause
  • Sclerostin

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