Comparison of Hemoglobins from Various Subjects Living in Hypoxia

R. I.N.I. PUSPITANINGRUM, KURNIA NUZTIR MANTOLINI, RUSDI, Mohamad Sadikin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of this research was to obtain the different characteristics of haemoglobin molecules in subjects under hypoxic condition, namely eel, catfish, suckermouth fish, green sea turtle using an electrophoresis technique. We used human umbilical cord blood and thalassemia patient blood, as well as a normal adult-human blood as controls. The proteins obtained after electrophoresis process were stained with two different colouring techniques, each based on different principles. Both staining techniques gave practically identical results. Subject that live in hypoxic condition has a different haemoglobin in comparison to the one found in adult human live in normal oxygen condition (normoxia). These hypoxia-adapted or -needed hemoglobin migrate slower than adult human hemoglobin from normoxia. This observation suggests that hemoglobin which is needed to live in hypoxic condition or environment is a different molecule. Whether this hemoglobin from hypoxic condition has a higher affinity to oxygen is not yet known. Further study is needed to clarify this issue.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalHAYATI Journal of Biosciences
Volume20
Issue number3
DOIs
Publication statusPublished - 1 Sep 2013

Keywords

  • Chelonia mydas
  • Clarias bathracus
  • haemoglobin protein content
  • human umbilical cord
  • Hyposarcus pardalis
  • Monopterus albus
  • β Thalassemia Patient and Human adult

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