TY - JOUR
T1 - Comparative Study of Calretinin Expression in Dentigerous Cyst, Odontogenic Keratocyst, and Unicystic Ameloblastoma
AU - Sunjaya, Hendro A.
AU - Fatah, Wlliam R.
AU - Rahadiani, Nur
AU - Vitria, Evy E.
N1 - Funding Information:
The authors would gratefully like to thank the anonymous reviewers for their useful comments and for their vocational guidance. This work was supported by Directorate of Research and Community Engagement Universitas Indonesia.
Publisher Copyright:
© 2021. All Rights Reserved.
PY - 2021
Y1 - 2021
N2 - Odontogenic cysts and tumors are aspects that often discussed and quite important in the field I of either oromaxillofacial surgery or pathology. Radiographically, the dentigerous cyst, odontogenic I keratocyst (OKC), and unicystic ameloblastoma have a similar appearance in the form of unilocular I radiolucent lesions. As a results of histopathological examination with hematoxylin eosin staining, I these three lesions can be distinguished, however, many pathologists are misdiagnosed because of I their similarity. Calretinin is a calcium binding protein that has been widely used for markers of I malignancy in human tissues, due to its role in cell apoptosis which causes cell proliferation. This study aims to observe and compare Calretinin expression in dentigerous cysts, OKC, and I unicystic ameloblastoma. 34 paraffin blocks of dentigerous cysts, OKC and unicystic ameloblastoma were obtained by I consecutive sampling from medical record data in the Cipto Mangunkusumo Hospital, Oral Surgery I Division which had confirmed histopathological results at the Department of Anatomical Pathology I Cipto Mangunkusumo Hospital during the period 2015-2019. All samples were subjected to I immunohistochemical staning using mouse monolclonal Calretinin antibodies. 13 samples of dentigerous cysts, 6 samples of OKC, and 15 samples monoklonal of unicystic I ameloblastoma were obtained. The positive interpretation of Calretinin was 1 sample of dentigerous I cyst and 11 samples of unicystic ameloblastoma. Using Chi-square test value of significancy was I 0,001 with odds ratio 49,5 (95% CI = 4.88 to 501.7). Calretinin was expressed in dentigerous cysts and unicystic ameloblastoma with different I percentages, but not in OKC. Calretinin can be used as a marker for unicystic ameloblastoma
AB - Odontogenic cysts and tumors are aspects that often discussed and quite important in the field I of either oromaxillofacial surgery or pathology. Radiographically, the dentigerous cyst, odontogenic I keratocyst (OKC), and unicystic ameloblastoma have a similar appearance in the form of unilocular I radiolucent lesions. As a results of histopathological examination with hematoxylin eosin staining, I these three lesions can be distinguished, however, many pathologists are misdiagnosed because of I their similarity. Calretinin is a calcium binding protein that has been widely used for markers of I malignancy in human tissues, due to its role in cell apoptosis which causes cell proliferation. This study aims to observe and compare Calretinin expression in dentigerous cysts, OKC, and I unicystic ameloblastoma. 34 paraffin blocks of dentigerous cysts, OKC and unicystic ameloblastoma were obtained by I consecutive sampling from medical record data in the Cipto Mangunkusumo Hospital, Oral Surgery I Division which had confirmed histopathological results at the Department of Anatomical Pathology I Cipto Mangunkusumo Hospital during the period 2015-2019. All samples were subjected to I immunohistochemical staning using mouse monolclonal Calretinin antibodies. 13 samples of dentigerous cysts, 6 samples of OKC, and 15 samples monoklonal of unicystic I ameloblastoma were obtained. The positive interpretation of Calretinin was 1 sample of dentigerous I cyst and 11 samples of unicystic ameloblastoma. Using Chi-square test value of significancy was I 0,001 with odds ratio 49,5 (95% CI = 4.88 to 501.7). Calretinin was expressed in dentigerous cysts and unicystic ameloblastoma with different I percentages, but not in OKC. Calretinin can be used as a marker for unicystic ameloblastoma
KW - Calretinin
KW - dentigerous cyst
KW - I expression
KW - odontogenic keratocyst
KW - unicystic ameloblastoma
UR - http://www.scopus.com/inward/record.url?scp=85116913124&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85116913124
SN - 1309-100X
VL - 14
SP - 965
EP - 969
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 3
ER -