Comparative Study of Calretinin Expression in Dentigerous Cyst, Odontogenic Keratocyst, and Unicystic Ameloblastoma

Odontogenic cysts and tumors are aspects that often discussed and quite important in the field I of either oromaxillofacial surgery or pathology. Radiographically, the dentigerous cyst, odontogenic I keratocyst (OKC), and unicystic ameloblastoma have a similar appearance in the form of unilocular I radiolucent lesions. As a results of histopathological examination with hematoxylin eosin staining, I these three lesions can be distinguished, however, many pathologists are misdiagnosed because of I their similarity. Calretinin is a calcium binding protein that has been widely used for markers of I malignancy in human tissues, due to its role in cell apoptosis which causes cell proliferation. This study aims to observe and compare Calretinin expression in dentigerous cysts, OKC, and I unicystic ameloblastoma. 34 paraffin blocks of dentigerous cysts, OKC and unicystic ameloblastoma were obtained by I consecutive sampling from medical record data in the Cipto Mangunkusumo Hospital, Oral Surgery I Division which had confirmed histopathological results at the Department of Anatomical Pathology I Cipto Mangunkusumo Hospital during the period 2015-2019. All samples were subjected to I immunohistochemical staning using mouse monolclonal Calretinin antibodies. 13 samples of dentigerous cysts, 6 samples of OKC, and 15 samples monoklonal of unicystic I ameloblastoma were obtained. The positive interpretation of Calretinin was 1 sample of dentigerous I cyst and 11 samples of unicystic ameloblastoma. Using Chi-square test value of significancy was I 0,001 with odds ratio 49,5 (95% CI = 4.88 to 501.7). Calretinin was expressed in dentigerous cysts and unicystic ameloblastoma with different I percentages, but not in OKC. Calretinin can be used as a marker for unicystic ameloblastoma